Liver Cirrhosis: Intravoxel Incoherent Motion MR Imaging-Pilot Study

被引：543

作者：

Luciani, Alain ^{[1
,2
]}

Vignaud, Alexandre ^{[6
]}

Cavet, Madeleine ^{[2
]}

Van Nhieu, Jeanne Tran ^{[1
,3
]}

Mallat, Ariane ^{[1
,4
]}

Ruel, Lucile ^{[2
]}

Laurent, Alexis ^{[5
]}

Deux, Jean-Francois ^{[2
]}

Brugieres, Pierre ^{[2
]}

Rahmouni, Alain ^{[2
]}

机构：

[1] INSERM, Unite U841, Equipe 17, Creteil, France

[2] CHU Henri Mondor, Grp Henri Mondor Albert Chenevier, AP HP, Dept Radiol, F-94010 Creteil, France

[3] CHU Henri Mondor, Grp Henri Mondor Albert Chenevier, AP HP, Dept Pathol, F-94010 Creteil, France

[4] CHU Henri Mondor, Grp Henri Mondor Albert Chenevier, AP HP, Dept Hepatol, F-94010 Creteil, France

[5] CHU Henri Mondor, Grp Henri Mondor Albert Chenevier, AP HP, Dept Liver Surg, F-94010 Creteil, France

[6] Siemens Med Solut France, St Denis, France

来源：

RADIOLOGY | 2008年 / 249卷 / 03期

关键词：

D O I：

10.1148/radiol.2493080080

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To retrospectively evaluate a respiratory-triggered diffusion-weighted (DW) magnetic resonance (MR) imaging sequence combined with parallel acquisition to allow the calculation of pure molecular-based (D) and perfusion-related (D*, f) diffusion parameters, on the basis of the intravoxel incoherent motion (IVIM) theory, to determine if these parameters differ between patients with cirrhosis and patients without liver fibrosis. Materials and Methods: The institutional review board approved this retrospective study; informed consent was waived. IVIM DW imaging was tested on three alkane phantoms, on which the signal-intensity decay curves according to b factors were logarithmically plotted. Ten b factors (0, 10, 20, 30, 50, 80, 100, 200, 400, 800 sec/mm(2)) were used in patients. Patients with documented liver cirrhosis (cirrhotic liver group, n = 12) and patients without chronic liver disease (healthy liver group, n = 25) were included. The mean liver D, D*, and f values were measured and compared with the apparent diffusion coefficient (ADC) computed by using four b values (0, 200, 400, 800 sec/mm2). Liver ADC and D, f, and D* parameters were compared between the cirrhotic liver group and healthy liver group. Means were compared by using the Student t test. Results: Signal-intensity decay curves were monoexponential on phantoms and biexponential in patients. In vivo, mean ADC values were significantly higher than D in the healthy liver group (ADC = 1.39 x 10(-3) mm(2)/sec +/- 0.2 [standard deviation] vs D = 1.10 x 10(-3) mm2/sec +/- 0.7) and in the cirrhotic liver group (ADC = 1.23 x 10(-3) mm(2)/sec +/- 0.4 vs D = 1.19 x 10(-3) mm(2)/sec +/- 0.5) (P = .03). ADC and D* were significantly reduced in the cirrhotic liver group compared with those in the healthy liver group (respective P values of .03 and .008). Conclusion: Restricted diffusion observed in patients with cirrhosis may be related to D* variations, which reflect decreased perfusion, as well as alterations in pure molecular water diffusion in cirrhotic livers. (C) RSNA, 2008

引用

页码：891 / 899

页数：9

共 37 条

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