Antifungal activity from Alpinia galanga and the competition for incorporation of unsaturated fatty acids in cell growth

被引：36

作者：

Haraguchi, H

Kuwata, Y

Inada, K

Shingu, K

Miyahara, K

Nagao, M

Yagi, A

机构：

[1] SETSUNAN UNIV, FAC PHARMACEUT SCI, HIRAKATA, OSAKA 57301, JAPAN

[2] FUKUYAMA UNIV, FAC PHARM & PHARMACEUT SCI, FUKUYAMA, HIROSHIMA 72902, JAPAN

来源：

PLANTA MEDICA | 1996年 / 62卷 / 04期

关键词：

Alpinia galanga (L) Willd; Zingiberaceae; (E)-8 beta,17-epoxylabd-12-ene-15,16-dial; antifungal activity; cell membrane; unsaturated fatty acids;

D O I：

10.1055/s-2006-957890

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

An antimicrobial diterpene was isolated from Alpinia galanga in the screening for potentiators of phytochemical antibiotic action. The structure was elucidated by spectral data and identified as (E)-8 beta,17-epoxylabd-12-ene-15,16-dial (1). Diterpene 1 synergistically enhanced the antifungal activity of quercetin and chalcone against Candida albicans. Antifungal activity of 1 was reversed by unsaturated fatty acids. Protoplasts of C. albicans were lysed by 1. These results suggest that antifungal activity of 1 is due to a change of membrane permeability arising from membrane lipid alternation.

引用

页码：308 / 313

页数：6

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