Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma

被引：126

作者：

Chen, Ya-Hong ^{[1
]}

Wu, Rui ^{[1
]}

Geng, Bin ^{[2
]}

Qi, Yong-Fen ^{[2
]}

Wang, Pei-Pei ^{[1
]}

Yao, Wan-Zhen ^{[1
]}

Tang, Chao-Shu ^{[2
]}

机构：

[1] Peking Univ, Hosp 3, Resp Dept, Beijing 100083, Peoples R China

[2] Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100083, Peoples R China

来源：

CYTOKINE | 2009年 / 45卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Asthma; Hydrogen sulfide; Airway inflammation; Airway remodeling; inducible nitric oxide synthase; NF-KAPPA-B; PULMONARY-HYPERTENSION; LIPOPOLYSACCHARIDE; INHIBITOR; INJURY; NEUROMODULATOR; EXPRESSION; CYTOKINES; MEDIATOR; PATHWAY;

D O I：

10.1016/j.cyto.2008.11.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endogenous hydrogen sulfide (H(2)S) is hypothesized to have an important role in systemic inflammation. We investigated if endogenous H(2)S may be a crucial mediator in airway inflammation and airway remodeling in a rat model of asthma and if endogenous H(2)S may exert its anti-inflammatory effect by inhibiting inducible nitric oxide synthase (iNOS)/NO pathway. Cystathionine-gamma-lyase (CSE; a H(2)S-synthesizing enzyme) was mainly expressed in airway and vascular smooth muscle cells in rat lung tissue. Levels of endogenous H(2)S was decreased in pulmonary tissue in ovalbumin (OVA)-treated rats. Exogenous administration of NaHS alleviated airway inflammation and airway remodeling: peak expiratory flow (PEF) increased, goblet cell hyperplasia and collagen deposition score decreased, with decreased total cells recovered from bronchoalveolar fluid (BALF) and influx of eosinophils and neutrophils. The H(2)S levels of serum and lung tissue were positively correlated with PEF and negatively correlated with the level of eosinophils and neutrophils in BALF, score of lung pathology. NaHS treatment significantly attenuated pulmonary iNOS activation in OVA-treated rats. These results suggest that the CSE/H(2)S pathway plays an anti-inflammatory and anti-remodeling part in asthma pathogenesis and could be a novel target in prevention and treatment of asthma. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：117 / 123

页数：7

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