Inhibitory effect of ND2001 on spontaneous multiple metastasis of NC 65 tumors derived from human renal cancer cells intradermally transplanted into nude mice

被引：2

作者：

Nakatsugawa, S

Okuda, T

Muramoto, H

Koyama, K

Ishigaki, T

Tsuruoka, T

Hosokawa, M

Nakatsugawa, S

机构：

[1] Nagoya Univ, Dept Radiol, Showa Ku, Nagoya, Aichi 4660065, Japan

[2] Meiji Seika Kaisha Ltd, Dept Med Res, Div Pharmaceut, Chuo Ku, Tokyo 1048002, Japan

[3] Hokkaido Univ, Sch Med, Inst Canc, Pathol Lab,Kita Ku, Sapporo, Hokkaido 0600815, Japan

来源：

ANTI-CANCER DRUGS | 1999年 / 10卷 / 02期

关键词：

antimetastatic agents; NC; 65; ND2001; nude mice; renal cell carcinoma;

D O I：

10.1097/00001813-199902000-00012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The NC 65 tumor cell line derived from human renal cell carcinoma was selected from among nine human cell lines by determining the inhibition of invasion by ND2001 (sodium D-glucaro-delta-lactam) in vitro. The efficacy of this agent against these tumor cells was investigated in an experimental metastatic model of human tumors in vivo. Although ND2001 did not inhibit growth of NC 65 cells intradermally transplanted into male KSN mice (nu/nu), this agent inhibited multiple spontaneous metastasis, [(C) 1999 Lippincott Williams & Wilkins.].

引用

页码：229 / 233

页数：5

共 15 条

[1]

ALBINI A, 1987, CANCER RES, V47, P3239

[2]

[Anonymous], METHODS CANC RES

[3]

DECLERCK YA, 1992, CANCER RES, V52, P701

[4]

HOEHN W, 1978, INVEST UROL, V16, P106

[5] A new anti-metastatic drug, ND-2001, inhibits lung metastases in rat hepatoma cells by suppressing haptotaxis of tumor cells toward laminin [J].

Kuramitsu, Y ;

Hamada, J ;

Tsuruoka, T ;

Morikawa, K ;

Kobayashi, H ;

Hosokawa, M .

ANTI-CANCER DRUGS, 1998, 9 (01) :88-92

[6]

LIOTTA LA, 1986, CANCER RES, V46, P1

[7] Tubulogenesis by microvascular endothelial cells is mediated by vascular endothelial growth factor (VEGF) in renal cell carcinoma [J].

Nakagawa, M ;

Emoto, A ;

Hanada, T ;

Nasu, N ;

Nomura, Y .

BRITISH JOURNAL OF UROLOGY, 1997, 79 (05) :681-687

[8]

Nakajima M, 1991, Semin Cancer Biol, V2, P115

[9]

NAKATSUGAWA S, 1992, JPN J CANC CLIN, V38, P1397

[10]

NAKATSUGAWA S, 1992, P 51 ANN M JAP CANC

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