Regulation of the androgen receptor by post-translational modifications

被引：112

作者：

Coffey, Kelly ^{[1
]}

Robson, Craig N. ^{[1
]}

机构：

[1] Newcastle Univ, Solid Tumour Target Discovery Grp, Sch Med, Newcastle Canc Ctr,No Inst Canc Res, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

JOURNAL OF ENDOCRINOLOGY | 2012年 / 215卷 / 02期

关键词：

PROSTATE-CANCER CELLS; ANTIHISTONE ACETYLTRANSFERASE ACTIVITY; LIGAND-INDEPENDENT ACTIVATION; GLYCOGEN-SYNTHASE KINASE-3-BETA; SERINE; 81; PHOSPHORYLATION; EPIDERMAL-GROWTH-FACTOR; PROTEIN-KINASE-C; TRANSCRIPTIONAL ACTIVITY; LNCAP CELLS; TYROSINE PHOSPHORYLATION;

D O I：

10.1530/JOE-12-0238

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The androgen receptor (AR) is a key molecule in prostate cancer and Kennedy's disease. Understanding the regulatory mechanisms of this steroid receptor is important in the development of potential therapies for these diseases. One layer of AR regulation is provided by post-translational modifications including phosphorylation, acetylation, sumoylation, ubiquitination and methylation. While these modifications have mostly been studied as individual events, it is becoming clear that these modifications can functionally interact with each other in a signalling pathway. In this review, the effects of all modifications are described with a focus on interplay between them and the functional consequences for the AR. Journal of Endocrinology (2012) 215, 221-237

引用

收藏

页码：221 / 237

页数：17

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