Transcriptional Regulation of the Warburg Effect in Cancer by SIX1

被引：251

作者：

Li, Ling ^{[1
]}

Liang, Yingchun ^{[1
]}

Kang, Lei ^{[1
,2
]}

Liu, Yang ^{[1
,3
]}

Gao, Shan ^{[4
]}

Chen, Siyu ^{[1
,3
]}

Li, Ying ^{[1
,5
]}

You, Wenye ^{[1
,5
]}

Dong, Qian ^{[1
]}

Hong, Tian ^{[1
]}

Yan, Zhifeng ^{[6
]}

Jin, Shuai ^{[1
,3
]}

Wang, Tao ^{[7
]}

Zhao, Wei ^{[8
]}

Mai, Haixing ^{[9
]}

Huang, Jun ^{[9
]}

Han, Xiao ^{[1
]}

Ji, Quanbo ^{[10
]}

Song, Qi

Yang, Chao ^{[8
]}

Zhao, Shixin ^{[1
]}

Xu, Xiaojie ^{[1
]}

Ye, Qinong ^{[1
]}

机构：

[1] Beijing Inst Biotechnol, Collaborat Innovat Ctr Canc Med, Dept Med Mol Biol, Beijing 100850, Peoples R China

[2] Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100034, Peoples R China

[3] Peoples Liberat Army Gen Hosp, Dept Thorac Surg, Beijing 100853, Peoples R China

[4] Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, CAS Key Lab Biomed Diagnost, Suzhou 215163, Peoples R China

[5] Peoples Liberat Army Gen Hosp, Dept Oncol, Beijing 100853, Peoples R China

[6] Peoples Liberat Army Gen Hosp, Dept Gynecol & Obstet, Beijing 100853, Peoples R China

[7] Peoples Liberat Army, Hosp 307, Dept Oncol, Beijing 100071, Peoples R China

[8] PLA Rocket Force, Gen Hosp, Dept Oncol, Beijing 100088, Peoples R China

[9] Peoples Liberat Army, Hosp 307, Dept Urol, Beijing 100071, Peoples R China

[10] Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China

来源：

CANCER CELL | 2018年 / 33卷 / 03期

关键词：

BREAST-CANCER; WILMS-TUMORS; 6; FAMILY; IN-VIVO; CELLS; METABOLISM; OVEREXPRESSION; GLYCOLYSIS; MUTATIONS; BETA;

D O I：

10.1016/j.ccell.2018.01.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Aerobic glycolysis (the Warburg effect) facilitates tumor growth, and drugs targeting aerobic glycolysis are being developed. However, how the Warburg effect is directly regulated is largely unknown. Here we show that transcription factor SIX1 directly increases the expression of many glycolytic genes, promoting the Warburg effect and tumor growth in vitro and in vivo. SIX1 regulates glycolysis through HBO1 and AIB1 histone acetyltransferases. Cancer-related SIX1 mutation increases its ability to promote aerobic glycolysis and tumor growth. SIX1 glycolytic function is directly repressed by microRNA-548a-3p, which is downregulated, inversely correlates with SIX1, and is a good predictor of prognosis in breast cancer patients. Thus, the microRNA-548a-3p/SIX1 axis strongly links aerobic glycolysis to carcinogenesis and may become a promising cancer therapeutic target.

引用

页码：368 / +

页数：25

共 40 条

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Anticancer strategies based on the metabolic profile of tumor cells: therapeutic targeting of the Warburg effect [J].