A new member of the frizzled family from Drosophila functions as a Wingless receptor

被引：1192

作者：

Bhanot, P

Brink, M

Samos, CH

Hsieh, JC

Wang, YS

Macke, JP

Andrew, D

Nathans, J

Nusse, R

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT MOLEC BIOL & GENET,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT CELL BIOL & ANAT,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205

[4] JOHNS HOPKINS UNIV,SCH MED,HOWARD HUGHES MED INST,BALTIMORE,MD 21205

[5] STANFORD UNIV,SCH MED,HOWARD HUGHES MED INST,STANFORD,CA 94305

[6] STANFORD UNIV,SCH MED,DEPT BIOL,STANFORD,CA 94305

来源：

NATURE | 1996年 / 382卷 / 6588期

关键词：

D O I：

10.1038/382225a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Receptors for Wingless and other signalling molecules of the Wnt gene family have yet to be identified. We show here that cultured Drosophila cells transfected with a novel member of the frizzled gene family in Drosophila, Dfz2, respond to added Wingless protein by elevating the level of the Armadillo protein. Moreover, Wingless binds to Drosophila or human cells expressing Dfz2. These data demonstrate that Dfz2 functions as a Wingless receptor, and they imply, in general, that Frizzled proteins are receptors for the Wnt signalling molecules.

引用

页码：225 / 230

页数：6

共 50 条

[1]

ADLER PN, 1990, GENETICS, V126, P401

[2] ALLELIC VARIATION AT THE FRIZZLED LOCUS OF DROSOPHILA [J].