Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH

被引：3

作者：

Armelin, HA ^{[1
]}

Lotfi, CFP ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508900 Sao Paulo, Brazil

来源：

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH | 1999年 / 32卷 / 07期

关键词：

adrenocortical cell cycle; ACTH; FGF2; ERK-MAPK; c-fos proto-oncogene;

D O I：

10.1590/S0100-879X1999000700007

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

FGF2 elicits a strong mitogenic response in the mouse Y-1 adrenocortical tumor cell line, that includes a rapid and transient activation of the ERK-MAPK cascade and induction of the c-Fos protein. ACTH, itself a very weak mitogen, blocks the mitogenic response effect of FGF2 in the early and middle G(1) phase, keeping both ERK-MAPK activation and c-Fos induction at maximal levels. probing the mitogenic response of Y-1 cells to FGF2 with ACTH is likely to uncover reactions underlying the effects of this hormone on adrenocortical cell growth.

引用

页码：841 / 843

页数：3

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