Comparative pharmacokinetics and interspecies scaling of amphotericin B in several mammalian species

被引:32
作者
Hutchaleelaha, A [1 ]
Chow, HH [1 ]
Mayersohn, M [1 ]
机构
[1] UNIV ARIZONA,COLL PHARM,DEPT PHARM PRACTICE & SCI,TUCSON,AZ 85721
关键词
D O I
10.1111/j.2042-7158.1997.tb06775.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This study employed several interspecies scaling methods, to evaluate the applicability of extrapolating to man, pharmacokinetic information obtained from animals for amphotericin B, an anti-fungal drug. Pharmacokinetic parameters from four animal species (mouse, rat, monkey and dog) and man were obtained from the literature or from analysis of data reported in the literature. The allometric relationships (obtained from four animal species) as a function of species body weight (W; kg) for systemic clearance per maximum life span potential (CL(S)/MLP), steady-state volume of distribution (V-SS), apparent volume of distribution (V-beta) and volume of the central compartment (V-C) were: 5691W(1-096); 2.46W(0.839); 3.08W(0.948) and 1.07W(0.965), respectively. The allometric relationships for half-life (h) and mean residence time (h) did not scale well with body weight. The prediction of pharmacokinetic parameters in man from the allometric equations do not always agree with those reported in the literature which are based upon a limited number of studies with few human subjects. The plasma concentration-time profiles from these animals were adjusted by normalizing the concentration with dose/W-0.948, and re-plotted on different pharmacokinetic time scales. The syndesichrons plot produced an almost superimposable profile of adjusted concentrations as a function of adjusted time among the four species.
引用
收藏
页码:178 / 183
页数:6
相关论文
共 23 条
[1]   BAYESIAN-ANALYSIS OF MINIMUM AIC PROCEDURE [J].
AKAIKE, H .
ANNALS OF THE INSTITUTE OF STATISTICAL MATHEMATICS, 1978, 30 (01) :9-14
[2]   PREVENTION OF AMPHOTERICIN-B-INDUCED NEPHROTOXICITY BY LOADING WITH SODIUM-CHLORIDE - A REPORT OF 1291 DAYS OF TREATMENT WITH AMPHOTERICIN-B WITHOUT RENAL-FAILURE [J].
ARNING, M ;
SCHARF, RE .
KLINISCHE WOCHENSCHRIFT, 1989, 67 (20) :1020-1028
[3]   AMPHOTERICIN-B PHARMACOKINETICS IN HUMANS [J].
ATKINSON, AJ ;
BENNETT, JE .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1978, 13 (02) :271-276
[4]   INTERSPECIES PHARMACOKINETIC SCALING AND THE EVOLUTIONARY-COMPARATIVE PARADIGM [J].
BOXENBAUM, H .
DRUG METABOLISM REVIEWS, 1984, 15 (5-6) :1071-1121
[5]   INTERSPECIES PHARMACOKINETIC SCALING AND THE DEDRICK PLOTS [J].
BOXENBAUM, H ;
RONFELD, R .
AMERICAN JOURNAL OF PHYSIOLOGY, 1983, 245 (06) :R768-R775
[6]   INTERSPECIES SCALING, ALLOMETRY, PHYSIOLOGICAL TIME, AND THE GROUND PLAN OF PHARMACOKINETICS [J].
BOXENBAUM, H .
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1982, 10 (02) :201-225
[7]   EVOLUTIONARY BIOLOGY, ANIMAL BEHAVIOR, 4TH-DIMENSIONAL SPACE, AND THE RAISON DETRE OF DRUG-METABOLISM AND PHARMACOKINETICS [J].
BOXENBAUM, H .
DRUG METABOLISM REVIEWS, 1983, 14 (05) :1057-1097
[8]   COCCIDIOIDOMYCOSIS IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME [J].
BRONNIMANN, DA ;
ADAM, RD ;
GALGIANI, JN ;
HABIB, MP ;
PETERSEN, EA ;
PORTER, B ;
BLOOM, JW .
ANNALS OF INTERNAL MEDICINE, 1987, 106 (03) :372-379
[9]   PHARMACOKINETICS AND TOXICITY OF CONTINUOUS INFUSION AMPHOTERICIN-B IN CANCER-PATIENTS [J].
CHABOT, GG ;
PAZDUR, R ;
VALERIOTE, FA ;
BAKER, LH .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1989, 78 (04) :307-310
[10]  
CHOW HH, 1992, DRUG METAB DISPOS, V20, P432