Social isolation selectively reduces hippocampal brain-derived neurotrophic factor without altering plasma corticosterone

被引：96

作者：

Scaccianoce, S ^{[1
]}

Del Bianco, P ^{[1
]}

Paolone, G ^{[1
]}

Caprioli, D ^{[1
]}

Modafferi, AME ^{[1
]}

Nencini, P ^{[1
]}

Badiani, A ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Human Physiol & Pharmacol, I-00185 Rome, Italy

来源：

BEHAVIOURAL BRAIN RESEARCH | 2006年 / 168卷 / 02期

关键词：

brain-derived neurotrophic factor; corticosterone; social isolation; hippocampus; rat; stress; prefrontal cortex; striatum;

D O I：

10.1016/j.bbr.2005.04.024

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

It is well known that housing conditions may alter several physiological and behavioral parameters. In this study, we have investigated whether a prolonged period of partial social isolation can modify central brain-derived neurotrophic (BDNF) concentrations. Male Sprague-Dawley rats were singly housed for 8 weeks before hippocampi, prefrontal cortices and striata were collected for BDNF determination. Compared to rats housed two per cage, isolated rats showed a significant reduction on BDNF protein concentrations in the hippocampus while no changes were observed in the other brain regions examined. Moreover, housing condition had no effect on basal plasma corticosterone. On the basis of the proposed etiological participation of reduced central BDNF concentrations in affective disorders, our results would candidate social isolation as a model for the study of antidepressant treatments. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：323 / 325

页数：3

共 28 条

[1] Social stress increases blood pressure and cardiovascular pathology in a normotensive rat model [J].

Andrews, E ;

Jenkins, C ;

Seachrist, D ;

Dunphy, G ;

Ely, D .

CLINICAL AND EXPERIMENTAL HYPERTENSION, 2003, 25 (02) :85-101

[2] BEHAVIORAL AND ADRENOCORTICAL REACTIVITY IN FEMALE MICE FOLLOWING INDIVIDUAL OR GROUP HOUSING [J].

BENTON, D ;

BRAIN, PF .

DEVELOPMENTAL PSYCHOBIOLOGY, 1981, 14 (02) :101-107

[3] Animal models of social stress: Effects on behavior and brain neurochemical systems [J].

Blanchard, RJ ;

McKittrick, CR ;

Blanchard, DC .

PHYSIOLOGY & BEHAVIOR, 2001, 73 (03) :261-271

[4]

Campbell S, 2004, J PSYCHIATR NEUROSCI, V29, P417

[5]

Carlson W. H., 1988, GREENHOUSE GROWER, V6, P12

[6] Antidepressants and neuroplasticity [J].

D'Sa, C ;

Duman, RS .

BIPOLAR DISORDERS, 2002, 4 (03) :183-194

[7] The disruption of prepulse inhibition by social isolation in the Wistar rat: How robust is the effect? [J].

Domeney, A ;

Feldon, J .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1998, 59 (04) :883-890

[8] Role of neurotrophic factors in the etiology and treatment of mood disorders [J].

Duman, RS .

NEUROMOLECULAR MEDICINE, 2004, 5 (01) :11-25

[9] Mild social stress abolishes the effects of isolation on anxiety and chlordiazepoxide reactivity [J].

Haller, J ;

Halász, J .

PSYCHOPHARMACOLOGY, 1999, 144 (04) :311-315

[10] Critical role of brain-derived neurotrophic factor in mood disorders [J].

Hashimoto, K ;

Shimizu, E ;

Iyo, M .

BRAIN RESEARCH REVIEWS, 2004, 45 (02) :104-114

← 1 2 3 →