Sohlh1 is essential for spermatogonial differentiation

被引：187

作者：

Ballow, D.

Meistrich, M. L.

Matzuk, M.

Rajkovic, A.

机构：

[1] Baylor Coll Med, Fac Ctr, Dept Obstet & Gynecol, Houston, TX 77030 USA

[2] Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

来源：

DEVELOPMENTAL BIOLOGY | 2006年 / 294卷 / 01期

关键词：

Sohlh1; transcription factor; spermatogonia; testes; Sohlh2; germ cell; spermatogenesis;

D O I：

10.1016/j.ydbio.2006.02.027

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Spermatogonia are adult germline stem cells that can both self-renew and differentiate into spermatocytes. Little is known about factors necessary for spermatogonial differentiation. We identified a novel germ-cell-specific transcription factor that we named Sohlh1 (spermatogenesis and oogenesis specific basic helix-loop-helix (bHLH) transcription factor). In males, Sohlh1 is preferentially expressed in prespermatogonia and Type A spermatogonia. Loss of Sohlh1 causes infertility by disrupting spermatogonial differentiation into spermatocytes. Seven-day-old testes without Sohlh1 still express the testis-specific transcription factors Etv5, Taf4b, Zfp148, and Plzf, overexpress a novel Sohlh2 bHLH transcription factor, but lack LIM homeobox gene Lhx8 and show reduced expression of Ngn3. Sohlh1 represents the first testis-specific bHLH transcription factor that is essential for sperniatogonial differentiation. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：161 / 167

页数：7

共 37 条

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