Cyclooxygenase-2 induction by adiponectin is regulated by a sphingosine kinase-1 dependent mechanism in cardiac myocytes

被引：54

作者：

Ikeda, Yasumasa ^{[1
]}

Ohashi, Koji ^{[1
]}

Shibata, Rei ^{[1
,2
]}

Pimentel, David R. ^{[3
,4
]}

Kihara, Shinji ^{[5
]}

Ouchi, Noriyuki ^{[1
]}

Walsh, Kenneth ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Mol Cardiol Whitaker Cardiovasc Inst, Boston, MA 02118 USA

[2] Nagoya Univ, Grad Sch Med, Dept Cardiol, Showa Ku, Nagoya, Aichi 4668550, Japan

[3] Boston Univ, Med Ctr, Dept Med, Cardiovasc Med Sect, Boston, MA 02118 USA

[4] Boston Univ, Sch Med, Myocardial Biol Unit, Boston, MA 02118 USA

[5] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan

来源：

FEBS LETTERS | 2008年 / 582卷 / 07期

关键词：

adiponectin; cyclooxygenase-2; sphingosine kinase-1; cardiac myocytes;

D O I：

10.1016/j.febslet.2008.03.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The adipose-derived plasma protein, adiponectin (APN), has various protective effects on cardiovascular diseases. In this study, we show that endogenous APN is required for full cyclooxygenase-2 (COX-2) induction by ischemia-reperfusion injury in the heart in vivo. In rat neonatal cardiac myocytes, APN-induced COX-2 expression was reduced by treatment with a sphingosine kinase-1 (SphK-1) inhibitor or siRNA targeting SphK-1. Treatment with a sphingosine-1-phosphate (S1P) receptor antagonist also diminished COX-2 expression in response to APN stimulation. These findings suggest that APN is a physiological regulator of COX-2 signaling in the heart and that this regulation occurs in part via a SphK-1-S1P receptor dependent mechanism in cardiac myocytes. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1147 / 1150

页数：4

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