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β-cell death during progression to diabetes

被引：721
作者：
Mathis, D
Vence, L
Benoist, C
机构：
[1] Brigham & Womens Hosp, Joslin Diabet Ctr, Dept Med, Sect Immunol & Innumogenet, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA 02215 USA
来源：
NATURE | 2001年 / 414卷 / 6865期
关键词：
D O I：
10.1038/414792a
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The hallmark of type 1 diabetes is specific destruction of pancreatic islet beta -cells. Apoptosis of beta -cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. beta -Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes.
引用
收藏
页码：792 / 798
页数：7
相关论文
共 104 条
  • [1] Transgenic overexpression of human Bcl-2 in islet β cells inhibits apoptosis but does not prevent autoimmune destruction
    Allison, J
    Thomas, H
    Beck, D
    Brady, JL
    Lew, AM
    Elefanty, A
    Kosaka, H
    Kay, TW
    Huang, DCS
    Strasser, A
    [J]. INTERNATIONAL IMMUNOLOGY, 2000, 12 (01) : 9 - 17
  • [2] Mechanisms of β cell death in diabetes:: A minor role for CD95
    Allison, J
    Strasser, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (23) : 13818 - 13822
  • [3] Perforin-independent β-cell destruction by diabetogenic CD8+ T lymphocytes in transgenic nonobese diabetic mice
    Amrani, A
    Verdaguer, J
    Anderson, B
    Utsugi, T
    Bou, S
    Santamaria, P
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (08) : 1201 - 1209
  • [4] INSULIN-DEPENDENT DIABETES-MELLITUS AS AN AUTOIMMUNE-DISEASE
    BACH, JF
    [J]. ENDOCRINE REVIEWS, 1994, 15 (04) : 516 - 542
  • [5] The NOD mouse - Introduction
    Bach, JF
    Mathis, D
    [J]. RESEARCH IN IMMUNOLOGY, 1997, 148 (05): : 285 - 286
  • [6] Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-γ
    Badovinac, VP
    Tvinnereim, AR
    Harty, JT
    [J]. SCIENCE, 2000, 290 (5495) : 1354 - 1357
  • [7] Irreversibility of nutritionally induced NIDDM in Psammomys obesus is related to β-cell apoptosis
    Bar-On, H
    Ben-Sasson, R
    Ziv, E
    Arar, N
    Shafrir, E
    [J]. PANCREAS, 1999, 18 (03) : 259 - 265
  • [8] Bellone M, 1997, J IMMUNOL, V159, P5391
  • [9] Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?
    Benoist, C
    Mathis, D
    [J]. NATURE IMMUNOLOGY, 2001, 2 (09) : 797 - 801
  • [10] Beutler BA, 1999, J RHEUMATOL, V26, P16
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