Neuroscience - Regulating energy balance: The substrate strikes back

被引：29

作者：

Flier, JS ^{[1
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Div Endocrinol, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Boston, MA 02215 USA

来源：

SCIENCE | 2006年 / 312卷 / 5775期

关键词：

D O I：

10.1126/science.1127971

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hormones and dietary nutrients control appetite and metabolism by acting on the brain, where the signals they elicit promote hunger or satiety. Neurons in the hypothalamus integrate these signals to regulate energy balance.

引用

页码：861 / +

页数：3

共 20 条

[1]

ANDERSON GH, 1994, MODERN NUTR HLTH DIS, P520

[2] Recent advances in the regulation of the TOR pathway by insulin and nutrients [J].

Avruch, J ;

Lin, YS ;

Long, XM ;

Murthy, S ;

Ortiz-Vega, S .

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2005, 8 (01) :67-72

[3] Extracellular amino acid profiles in the paraventricular nucleus of the rat hypothalamus are influenced by diet composition [J].

Choi, YH ;

Fletcher, PJ ;

Anderson, GH .

BRAIN RESEARCH, 2001, 892 (02) :320-328

[4] Hypothalamic mTOR signaling regulates food intake [J].

Cota, D ;

Proulx, K ;

Smith, KAB ;

Kozma, SC ;

Thomas, G ;

Woods, SC ;

Seeley, RJ .

SCIENCE, 2006, 312 (5775) :927-930

[5] Mammalian TOR: A homeostatic ATP sensor [J].

Dennis, PB ;

Jaeschke, A ;

Saitoh, M ;

Fowler, B ;

Kozma, SC ;

Thomas, G .

SCIENCE, 2001, 294 (5544) :1102-1105

[6] Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex [J].

Hao, SZ ;

Sharp, JW ;

Ross-Inta, CM ;

McDaniel, BJ ;

Anthony, TG ;

Wek, RC ;

Cavener, DR ;

McGrath, BC ;

Rudell, JB ;

Koehnle, TJ ;

Gietzen, DW .

SCIENCE, 2005, 307 (5716) :1776-1778

[7] Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism [J].

Hara, K ;

Yonezawa, K ;

Weng, QP ;

Kozlowski, MT ;

Belham, C ;

Avruch, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (23) :14484-14494

[8] Complexity of the TOR signaling network [J].

Inoki, K ;

Guan, KL .

TRENDS IN CELL BIOLOGY, 2006, 16 (04) :206-212

[9] TSC2 mediates cellular energy response to control cell growth and survival [J].

Inoki, K ;

Zhu, TQ ;

Guan, KL .

CELL, 2003, 115 (05) :577-590

[10] TOR signalling in bugs, brain and brawn [J].

Jacinto, E ;

Hall, MN .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (02) :117-126

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