Influence of acute and repeated interleukin-2 administration on spatial learning, locomotor activity, exploratory behaviors, and anxiety

被引:46
作者
Lacosta, S
Merali, Z
Anisman, H
机构
[1] Carleton Univ, Inst Neurosci, Ottawa, ON K1S 5B6, Canada
[2] Univ Ottawa, Sch Psychol, Ottawa, ON K1N 6N5, Canada
[3] Univ Ottawa, Dept Cellular & Nucl Med, Ottawa, ON K1N 6N5, Canada
关键词
D O I
10.1037/0735-7044.113.5.1030
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Interleukin-2 (IL-2), released from activated T cells, influences central neurochemical functioning, and IL-2 immunotherapy in cancer patients may provoke neuropsychiatric and cognitive disturbances. In this study, acute, systemic IL-2 did not influence Morris water-maze performance in mice. In contrast, chronic IL-2 impaired performance when the position of the escape platform varied over days but was without effect when the platform position was fixed. These effects could not be attributed to illness, because IL-I beta, which induces marked malaise, did not influence water-maze performance. Chronic IL-2 produced modest reductions in exploration and approach to a novel stimulus, effects not seen after acute treatment, but did not influence spontaneous alternation performance or behavior in an elevated plus-maze test. Thus, repeated IL-2 may influence spatial working memory without affecting habituation/attentional attentional processes or anxiety.
引用
收藏
页码:1030 / 1041
页数:12
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