OPINION The consequences of asynapsis for mammalian meiosis

被引：284

作者：

Burgoyne, Paul S. ^{[1
]}

Mahadevaiah, Shantha K. ^{[1
]}

Turner, James M. A. ^{[1
]}

机构：

[1] Natl Inst Med Res, Ridgeway, MRC, Div Stem Cell Biol & Dev Genet, London NW7 1AA, England

来源：

NATURE REVIEWS GENETICS | 2009年 / 10卷 / 03期

基金：

英国医学研究理事会;

关键词：

HISTONE H2AX PHOSPHORYLATION; SEX-CHROMOSOME INACTIVATION; DOUBLE-STRAND BREAKS; MOUSE X-CHROMOSOME; MEIOTIC CHROMOSOMES; SPINDLE CHECKPOINT; PROPHASE ARREST; CROSSING-OVER; GERM-CELLS; MICE;

D O I：

10.1038/nrg2505

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

During mammalian meiosis, synapsis of paternal and maternal chromosomes and the generation of DNA breaks are needed to allow reshuffling of parental genes. In mammals errors in synapsis are associated with a male-biased meiotic impairment, which has been attributed to a response to persisting DNA double-stranded breaks in the asynapsed chromosome segments. Recently it was discovered that the chromatin of asynapsed chromosome segments is transcriptionally silenced, providing new insights into the connection between asynapsis and meiotic impairment.

引用

页码：207 / 216

页数：10

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