The effectiveness of borneol on pharmacokinetics changes of four ginsenosides in Shexiang Baoxin Pill in vivo

被引：34

作者：

Jiang, Peng ^{[1
,2
]}

Fu, Peng ^{[3
]}

Xiang, Li ^{[1
]}

Wang, Shuping ^{[1
]}

Liu, Xiaojun ^{[1
]}

Yang, Ling ^{[4
]}

Tao, Jianfei ^{[5
]}

Chen, Zhongliang ^{[2
]}

Zhan, Changsen ^{[2
]}

Huang, Ximing ^{[2
]}

Liu, Runhui ^{[1
]}

Zhang, Weidong ^{[1
,4
,6
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China

[2] Shanghai Hutchison Pharmaceut Co, Shanghai 200331, Peoples R China

[3] Second Mil Med Univ, Changhai Hosp, Dept Pharm, Shanghai 200433, Peoples R China

[4] Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China

[5] Shanghai Yangsi Hosipital, Dept Pharm, Shanghai 200126, Peoples R China

[6] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200030, Peoples R China

来源：

BIOMEDICAL CHROMATOGRAPHY | 2014年 / 28卷 / 03期

基金：

中国国家自然科学基金;

关键词：

pharmacokinetic; rat plasma; ginsenoside; borneol; Shexiang Baoxin Pill; TANDEM MASS-SPECTROMETRY; PANAX-NOTOGINSENG; RAT PLASMA; MYOCARDIAL-INFARCTION; GINSENG SAPONINS; ABSORPTION; RB-1; METABOLISM; EXCRETION; RG(1);

D O I：

10.1002/bmc.3037

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Shexiang Baoxin Pill (SBP) is a traditional Chinese medicine, widely used for cardiovascular diseases in the clinic. Ginsenosides are important effective components in SBP, but their pharmacokinetic characteristics are still not known. In this paper, we studied the pharmacokinetics of ginsenoside Rb1, Rc, Re and Rg1 in SBP and investigated the effect of borneol on the pharmacokinetic characteristic of ginsenosides based on an Agilent G6410A triple quadrupole LC/MS system. Results showed that the pharmacokinetic parameters of ginsenoside Rb1, Rc, Re and Rg1 in rat plasma after oral administration of SBP are significantly different with oral administration of SBP without Borneolum Syntheticum. Plasma pharmacokinetic profiles after oral administration of ginsenoside Rb1, Rc, Re, Rg1 and co-administration with borneol at three different ratios (10:1, 1:1 and 1:10 ginsenoside vs borneol, w/w) were also determined. It was demonstrated that borneol can elevate the plasma concentration of ginsenosides after co-admininstration. Copyright (c) 2013 John Wiley & Sons, Ltd.

引用

页码：419 / 427

页数：9

共 30 条

[1] Effect of P-glycoprotein inhibitor, verapamil, on oral bioavailability and pharmacokinetics of irinotecan in rats [J].

Bansal, Tripta ;

Mishra, Gautam ;

Jaggi, Manu ;

Khar, Roop K. ;

Talegaonkar, Sushama .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 36 (4-5) :580-590

[2] Liquid chromatography-electrospray ionization mass spectrometry for metabolism and pharmacokinetic studies of ginsenoside Rg3 [J].

Cai, ZW ;

Qian, TX ;

Wong, RNS ;

Jiang, ZH .

ANALYTICA CHIMICA ACTA, 2003, 492 (1-2) :283-293

[3] Simultaneous determination of three major bioactive saponins of Panax notoginseng using liquid chromatography-tandem mass spectrometry and a pharmacokinetic study [J].

Chen W. ;

Dang Y. ;

Zhu C. .

Chinese Medicine, 5 (1)

[4] Determination of ginsenoside Rc in rat plasma by LC-MS/MS and its application to a pharmacokinetic study [J].

Chu, Yang ;

Zhang, Hong-chao ;

Li, Shu-ming ;

Wang, Jun-mei ;

Wang, Xiang-yang ;

Li, Wei ;

Zhang, Lan-lan ;

Ma, Xiao-hui ;

Zhou, Shui-ping ;

Zhu, Yong-hong ;

Liu, Chang-xiao .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2013, 919 :75-78

[5] Gas chromatographic-mass spectrometric determination of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol for study on human urinary excretion of ginsenosides after ingestion of ginseng preparations [J].

Cui, JF ;

Bjorkhem, I ;

Eneroth, P .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1997, 689 (02) :349-355

[6] Simultaneous determination of notoginsenoside R1, ginsenoside Rg1, Re, Rb1 and icariin in rat plasma by ultra-performance liquid chromatography-tandem mass spectrometry [J].

Deng, Gui-feng ;

Wang, Ding-li ;

Meng, Ming-xin ;

Hu, Fan ;

Yao, Tong-wei .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2009, 877 (22) :2113-2122

[7] Main Ginseng saponin metabolites formed by intestinal bacteria [J].

Hasegawa, H ;

Sung, JH ;

Matsumiya, S ;

Uchiyama, M .

PLANTA MEDICA, 1996, 62 (05) :453-457

[8] Effects of borneol on the intestinal transport and absorption of two P-glycoprotein substrates in rats [J].

He, Huijuan ;

Shen, Qi ;

Li, Jian .

ARCHIVES OF PHARMACAL RESEARCH, 2011, 34 (07) :1161-1170

[9] Simultaneous determination of ginsenoside Rb1 and Rg1 in human plasma by liquid chromatography-mass spectrometry [J].

Ji, HY ;

Lee, HW ;

Kim, HK ;

Kim, HH ;

Chang, SG ;

Sohn, DH ;

Kim, J ;

Lee, HS .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2004, 35 (01) :207-212

[10] Biomarkers in the early period of acute myocardial infarction in rat serum and protective effects of Shexiang Baoxin Pill using a metabolomic method [J].

Jiang, Peng ;

Dai, Weixing ;

Yan, Shikai ;

Chen, Zhongliang ;

Xu, Ruilin ;

Ding, Jianmi ;

Xiang, Li ;

Wang, Shuping ;

Liu, Runhui ;

Zhang, Weidong .

JOURNAL OF ETHNOPHARMACOLOGY, 2011, 138 (02) :530-536

← 1 2 3 →