Collagen scaffolds with tailored pore geometry for building three-dimensional vascular networks

被引：11

作者：

Berdichevski, A. ^{[1
]}

Birch, M. A. ^{[2
]}

Markaki, A. E. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Engn, Trumpington St, Cambridge CB2 1PZ, England

[2] Univ Cambridge, Addenbrookes Hosp, Dept Surg, Div Trauma & Orthopaed Surg, Cambridge CB2 0QQ, England

来源：

MATERIALS LETTERS | 2019年 / 248卷

基金：

英国工程与自然科学研究理事会;

关键词：

Biomaterials; Porous materials; Pore structure; Specific permeability; Vascularization; Collagen; ARCHITECTURE;

D O I：

10.1016/j.matlet.2019.03.137

中图分类号：

T [工业技术];

学科分类号：

120111 [工业工程];

摘要：

Collagen scaffolds provide a promising platform for tissue regeneration due to their ability to support cell attachment, proliferation and differentiation. In this study, we used porous freeze-dried collagen scaffolds with either uniaxially-aligned or randomly-oriented pores to investigate the formation of vascular structures in vitro. We characterised the scaffold pore structure, specific permeability, cell migration and endothelial cell self-assembly into vessel-like networks in mono- and co-culture with osteoblasts. Our work shows that improved pre-vascularisation can be achieved in uniaxially-aligned scaffolds and in a co-culture environment. (C) 2019 Elsevier B.V. All rights reserved.

引用

收藏

页码：93 / 96

页数：4

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