Chinese hamster ovary cell mutants affecting cholesterol metabolism

被引：28

作者：

Chang, TY

Hasan, MT

Chin, J

Chang, CCY

Spillane, DM

Chen, J

机构：

[1] Department of Biochemistry, Dartmouth Medical School, Hanover, NH

[2] Department of Biochemistry, Dartmouth Medical School, Hanover

来源：

CURRENT OPINION IN LIPIDOLOGY | 1997年 / 8卷 / 02期

关键词：

D O I：

10.1097/00041433-199704000-00003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The approach of somatic cell and molecular genetics for the study of intracellular regulation of cholesterol metabolism has blossomed in recent years, This review lists all the Chinese hamster ovary cell mutants involved in cholesterol metabolism. In addition, it summarizes the characteristics of mutants involved in three different processes: (1) sequential cleavage of the membrane-bound sterol regulatory element-binding proteins; (2) cholesterol esterification; and (3) intracellular cholesterol transport from the lysosome/endosome.

引用

页码：65 / 71

页数：7

共 78 条

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