α-D-Glucosidase inhibitory activity of polysaccharide isolated from Acacia tortilis gum exudate

被引：49

作者：

Bisht, Swati ^{[1
,2
]}

Kant, Ravi ^{[2
]}

Kumar, Vineet ^{[1
]}

机构：

[1] Forest Res Inst, Div Chem, Dehra Dun 248006, Uttar Pradesh, India

[2] SGRRITS, Div Pharmaceut, Dept Pharmacol, Dehra Dun 248001, Uttar Pradesh, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2013年 / 59卷

关键词：

Acacia tortilis; Gum exudate; Polysaccharide; alpha-D-Glucosidase; Postprandial blood glucose; Hyperglycemia; ACARBOSE; EXTRACT;

D O I：

10.1016/j.ijbiomac.2013.04.057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The study aims to explore the antihyperglycemic activity of Acacia tortilis polysaccharide isolated from the gum exudate. alpha-D-Glucosidase from Saccharomyces cerevisiae and rat small intestine was used as in vitro model to assess alpha-D-glucosidase inhibitory activity of the polysaccharide against yeast and mammalian enzyme. The reduction in postprandial blood glucose level after carbohydrate rich diet fed to Albino Wistar rats was employed as in vivo model of alpha-D-glucosidase inhibition. The study revealed alpha-D-glucosidase inhibitory activity of the polysaccharide in both in vitro as well as in vivo models. Therefore, polysaccharide isolated from A. tortilis plant gum exudate may be a potential drug for diabetes mellitus and its complications. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：214 / 220

页数：7

共 40 条

[1]

Ahmad G., 2008, IRAN J BASIC MED SCI, V11, P1

[2]

Inhibitory Activities of Cyanidin and Its Glycosides and Synergistic Effect with Acarbose against Intestinal α-Glucosidase and Pancreatic α-Amylase [J].

Akkarachiyasit, Sarinya ;

Charoenlertkul, Piyawan ;

Yibchok-anun, Sirintorn ;

Adisakwattana, Sirichai .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2010, 11 (09) :3387-3396

[3]

STUDIES OF URONIC ACID MATERIALS .45. COMPOSITION AND PROPERTIES OF GUM EXUDATES FROM SUBSPECIES OF ACACIA-TORTILIS [J].

ANDERSON, DM ;

BELL, PC .

PHYTOCHEMISTRY, 1974, 13 (09) :1875-1877

[4]

[Anonymous], 1995, WEALTH INDIA RAW MAT, V1, P46

[5]

[Anonymous], 2006, WEALTH INDIA DICT IN, V1, P11

[6]

[Anonymous], 2011, EVID BASED COMPL ALT, DOI [DOI 10.1093/ecam/nen040, DOI 10.1093/ECAM/NEN040]

[7]

Christudas Sunil Christudas Sunil, 2009, International Journal of Integrative Biology, V6, P41

[8]

Dey Lucy, 2002, Altern Med Rev, V7, P45

[9]

Oral agents for the treatment of type 2 diabetes mellitus: Pharmacology, toxicity, and treatment [J].

Harrigan, RA ;

Nathan, MS ;

Beattie, P .

ANNALS OF EMERGENCY MEDICINE, 2001, 38 (01) :68-78

[10]

Hong G., 2008, BIOSCIENCE BIOTECHNO, V72, P601

← 1 2 3 4 →