Regeneration gaps - Observations on stem cells and cardiac repair

被引：292

作者：

Murry, CE ^{[1
]}

Reinecke, H ^{[1
]}

Pabon, LM ^{[1
]}

机构：

[1] Univ Washington, Ctr Cardiovasc Biol & Regenerat Med, Seattle, WA 98109 USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2006年 / 47卷 / 09期

关键词：

D O I：

10.1016/j.jacc.2006.02.002

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Substantial evidence indicates that cell transplantation can improve function of the infarcted heart. A surprisingly wide range of non-myogenic cell types improves ventricular function, suggesting that benefit may result in part from mechanisms that are distinct from true myocardial regeneration. While clinical trials explore cells derived from skeletal muscle and bone marrow, basic researchers are investigating sources of new cardiomyocytes, such as resident myocardial progenitors and embryonic stem cells. In this commentary, we briefly review the evolution of cell-based cardiac repair, discuss the current state of clinical research, and offer some thoughts on how newcomers can critically evaluate this emerging field.

引用

页码：1777 / 1785

页数：9

共 101 条

[1]

Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling [J].

Aicher, A ;

Brenner, W ;

Zuhayra, M ;

Badorff, C ;

Massoudi, S ;

Assmus, B ;

Eckey, T ;

Henze, E ;

Zeiher, AM ;

Dimmeler, S .

CIRCULATION, 2003, 107 (16) :2134-2139

[2]

Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes [J].

Alvarez-Dolado, M ;

Pardal, R ;

Garcia-Vardugo, JM ;

Fike, JR ;

Lee, HO ;

Pfeffer, K ;

Lois, C ;

Morrison, SJ ;

Alvarez-Buylla, A .

NATURE, 2003, 425 (6961) :968-973

[3]

Amado LC, 2005, P NATL ACAD SCI USA, V102, P11474, DOI 10.1073/pnas.0504388102

[4]

Isolation of putative progenitor endothelial cells for angiogenesis [J].

Asahara, T ;

Murohara, T ;

Sullivan, A ;

Silver, M ;

vanderZee, R ;

Li, T ;

Witzenbichler, B ;

Schatteman, G ;

Isner, JM .

SCIENCE, 1997, 275 (5302) :964-967

[5]

Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy [J].

Askari, AT ;

Unzek, S ;

Popovic, ZB ;

Goldman, CK ;

Forudi, F ;

Kiedrowski, M ;

Rovner, A ;

Ellis, SG ;

Thomas, JD ;

DiCorleto, PE ;

Topol, EJ ;

Penn, MS .

LANCET, 2003, 362 (9385) :697-703

[6]

Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction -: (TOPCARE-AMI) [J].

Assmus, B ;

Schächinger, V ;

Teupe, C ;

Britten, M ;

Lehmann, R ;

Döbert, N ;

Grünwald, F ;

Aicher, A ;

Urbich, C ;

Martin, H ;

Hoelzer, D ;

Dimmeler, S ;

Zeiher, AM .

CIRCULATION, 2002, 106 (24) :3009-3017

[7]

Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium [J].

Balsam, LB ;

Wagers, AJ ;

Christensen, JL ;

Kofidis, T ;

Weissman, IL ;

Robbins, RC .

NATURE, 2004, 428 (6983) :668-673

[8]

Stem cell differentiation requires a paracrine pathway in the heart [J].

Behfar, A ;

Zingman, LV ;

Hodgson, DM ;

Rauzier, JM ;

Kane, GC ;

Terzic, A ;

Pucéat, M .

FASEB JOURNAL, 2002, 16 (12) :1558-1566

[9]

Adult cardiac stem cells are multipotent and support myocardial regeneration [J].

Beltrami, AP ;

Barlucchi, L ;

Torella, D ;

Baker, M ;

Limana, F ;

Chimenti, S ;

Kasahara, H ;

Rota, M ;

Musso, E ;

Urbanek, K ;

Leri, A ;

Kajstura, J ;

Nadal-Ginard, B ;

Anversa, P .

CELL, 2003, 114 (06) :763-776

[10]

Mobilization and homing of bone marrow stromal cells in myocardial infarction [J].

Bittira, B ;

Shum-Tim, D ;

Al-Khaldi, A ;

Chiu, RCJ .

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2003, 24 (03) :393-398

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