Enantioselective synthesis of phospholanes using chiral lithium amide desymmetrisation

被引：12

作者：

Blake, AJ ^{[1
]}

Hume, SC ^{[1
]}

Li, WS ^{[1
]}

Simpkins, NS ^{[1
]}

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

来源：

TETRAHEDRON | 2002年 / 58卷 / 23期

基金：

英国工程与自然科学研究理事会;

关键词：

asymmetric synthesis; chiral lithium amide; phospholane;

D O I：

10.1016/S0040-4020(02)00366-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselective deprotonation of 1,2,5-triphenylphospholane oxide with a chiral base, followed by electrophilic quenching, gives a range of chiral products in good yield and in ca. 85% ee. The absolute and relative configuration of two of the products was determined by X-ray crystallography. A number of the chiral phospholane oxides were subjected to further transformations, in particular reduction to give enantiomerically pure phospholanes. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：4589 / 4602

页数：14

共 21 条

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