FGF23 production by osteocytes

被引：99

作者：

Bonewald, Lynda F. ^{[1
]}

Wacker, Michael J. ^{[2
]}

机构：

[1] Univ Missouri, Sch Dent, Kansas City, MO 64108 USA

[2] Univ Missouri, Sch Med, Kansas City, MO 64108 USA

来源：

PEDIATRIC NEPHROLOGY | 2013年 / 28卷 / 04期

关键词：

Fibroblast growth factor 23; Phosphate homeostasis; Osteocytes; Bone metabolism; Cardiovascular disease; FIBROBLAST-GROWTH-FACTOR; CARDIOVASCULAR-DISEASE; PATHOGENIC ROLE; BONE-FORMATION; PEX GENE; MEPE; EXPRESSION; PHOSPHATE; RECEPTOR; RICKETS;

D O I：

10.1007/s00467-012-2309-3

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

Fibroblast Growth Factor 23 (FGF23), a known regulator of phosphate homeostasis, is produced by cells residing in bone, namely, osteocytes, to target a distant organ, the kidney. Elevated FGF23 levels have recently been found systemically and in osteocytes in patients and animal models of chronic kidney disease. Associations between serum FGF23 level and vascular dysfunction, vascular calcification, and increased risk of cardiovascular disease have also been observed. In this review we discuss FGF23 expression in osteocytes and the potential means to regulate expression and function of this protein at the osteocyte level.

引用

页码：563 / 568

页数：6

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