Fecal Markers of Intestinal Inflammation and Permeability Associated with the Subsequent Acquisition of Linear Growth Deficits in Infants

被引：241

作者：

Kosek, Margaret ^{[1
]}

Hague, Rashidul ^{[2
]}

Lima, Aldo ^{[3
]}

Babji, Sudhir ^{[4
]}

Shrestha, Sanjaya ^{[5
]}

Qureshi, Shahida ^{[6
]}

Amidou, Samie ^{[7
]}

Mduma, Estomih ^{[8
]}

Lee, Gwenyth ^{[1
]}

Yori, Pablo Penataro ^{[1
]}

Guerrant, Richard L. ^{[9
]}

Bhutta, Zulfiqar ^{[10
]}

Mason, Carl

Kang, Gagandeep ^{[4
]}

Kabir, Mamun ^{[11
]}

Amour, Caroline ^{[8
]}

Bessong, Pascal ^{[12
]}

Turab, Ali ^{[6
]}

Seidman, Jessica

Olortegui, Maribel Paredes

Quetz, Josiane ^{[3
]}

Lang, Dennis

Gratz, Jean ^{[9
]}

Miller, Mark

Gottlieb, Michael ^{[13
]}

机构：

[1] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA

[2] ICDDR B, Ctr Vaccine Sci, Dhaka, Bangladesh

[3] Univ Fed Ceara, Fortaleza, Ceara, Brazil

[4] Christian Med Coll & Hosp, Dept Gastrointestinal Sci, Vellore, Tamil Nadu, India

[5] AFRIMS Res Unit Nepal WARUN, Kathmandu, Nepal

[6] Aga Khan Univ, Dept Pediat & Child Hlth, Karachi, Pakistan

[7] Univ Venda, Thohoyandou, Limpopo Provinc, South Africa

[8] Haydom Lutheran Hosp, Manraya, Tanzania

[9] Univ Virginia, Ctr Global Hlth, Charlottesville, VA USA

[10] Aga Khan Univ, Div Women & Child Hlth, Karachi, Pakistan

[11] ICDDR B, Dept Parasitol, Dhaka, Bangladesh

[12] Univ Venda, Dept Microbiol, Thohoyandou, Limpopo Provinc, South Africa

[13] Fdn Natl Inst Hlth, Bethesda, MD USA

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2013年 / 88卷 / 02期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

CHILD UNDERNUTRITION; NUTRITIONAL-STATUS; URINARY NEOPTERIN; ENTEROPATHY; DIARRHEA; ALPHA-1-ANTITRYPSIN; MALNUTRITION; HEALTH;

D O I：

10.4269/ajtmh.2012.12-0549

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Enteric infections are associated with linear growth failure in children. To quantify the association between intestinal inflammation and linear growth failure three commercially available enzyme-linked immunosorbent assays (neopterin [NEO], alpha-anti-trypsin [AAT], and myeloperoxidase [MPO]) were performed in a structured sampling of asymptomatic stool from children under longitudinal surveillance for diarrhea] illness in eight countries. Samples from 537 children contributed 1,169 AAT, 916 MPO, and 954 NEO test results that were significantly associated with linear growth. When combined to form a disease activity score, children with the highest score grew 1.08 cm less than children with the lowest score over the 6-month period following the tests after controlling for the incidence of diarrheal disease. This set of affordable non-invasive tests delineates those at risk of linear growth failure and may be used for the improved assessments of interventions to optimize growth during a critical period of early childhood.

引用

页码：390 / 396

页数：7

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