Alterations of c-fos gene methylation in the processes of aging and tumorigenesis in human liver

被引：39

作者：

Choi, EK

Uyeno, S

Nishida, N

Okumoto, T

Fujimura, S

Aoki, Y

Nata, M

Sagisaka, K

Fukuda, Y

Nakao, K

Yoshimoto, T

Kim, YS

Ono, T

机构：

[1] TOHOKU UNIV, SCH MED, DEPT RADIAT RES, AOBA KU, SENDAI, MIYAGI 98077, JAPAN

[2] HALLYM UNIV, INST ENVIRONM & LIFE SCI, CHUNCHON 200702, SOUTH KOREA

[3] TOHOKU UNIV, SCH MED, DEPT NEUROSURG, AOBA KU, SENDAI, MIYAGI 98077, JAPAN

[4] KYOTO UNIV, GRAD SCH MED, DEPT MED & CLIN SCI, SAKYO KU, KYOTO 606, JAPAN

[5] TOHOKU UNIV, SCH MED, DEPT FORENS MED, AOBA KU, SENDAI, MIYAGI 98077, JAPAN

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1996年 / 354卷 / 01期

关键词：

c-fos; DNA methylation; aging; tumorigenesis; human liver;

D O I：

10.1016/0027-5107(96)00056-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The state of DNA methylation in the c-fos gene was examined in human livers of different ages, cirrhosis and hepatocellular carcinoma, The degree of methylation in the intron 1 to exon 4 region increased with age, whereas all of the 10 cirrhosis samples revealed a decrease in methylation when compared to normal livers of similar ages. The 11 hepatocellular carcinomas showed varied alterations suggesting that the alteration of the c-Sos gene methylation is related to aging as well as to early-step of hepatocarcinogenesis.

引用

页码：123 / 128

页数：6

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