Anticancer properties of polysaccharides isolated from fungi of the Basidiomycetes class

被引：83

作者：

Lemieszek, Marta ^{[1
]}

Rzeski, Wojciech ^{[1
,2
]}

机构：

[1] Inst Agr Med, Dept Med Biol, PL-20090 Lublin, Poland

[2] UMCS Lublin, Dept Virol & Immunol, Lublin, Poland

来源：

WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY | 2012年 / 16卷 / 04期

关键词：

Basidiomycetes; anticancer properties; polysaccharides; lentinan; PSK; Krestin; schizophyllan; PROTEIN-BOUND POLYSACCHARIDE; CYTOKINE STIMULATING ACTIVITY; BLOOD MONONUCLEAR-CELLS; ANTITUMOR-ACTIVITY; BETA-GLUCAN; PERIPHERAL-BLOOD; IMMUNOMODULATING CYTOKINES; PHYSICOCHEMICAL PROPERTIES; CHEMICAL-MODIFICATION; MEDICINAL MUSHROOMS;

D O I：

10.5114/wo.2012.30055

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Basidiomycete mushrooms represent a valuable source of biologically active compounds with anticancer properties. This feature is primarily attributed to polysaccharides and their derivatives. The anticancer potential of polysaccharides is linked to their origin, composition and chemical structure, solubility and method of isolation. Moreover, their activity can be significantly increased by chemical modifications. Anticancer effects of polysaccharides can be expressed indirectly (immunostimulation) or directly (cell proliferation inhibition and/or apoptosis induction). Among the wide range of polysaccharides with documented anticancer properties, lentinan, polysaccharide-K (PSK) and schizophyllan deserve special attention. These polysaccharides for many years have been successfully applied in cancer treatment and their mechanism of action is the best known.

引用

页码：285 / 289

页数：5

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