A quantitative approach to signal transduction

被引：8

作者：

Metzger, H

Chen, HX

Goldstein, B

Haleem-Smith, H

Inman, JK

Peirce, M

Torigoe, C

Vonakis, B

Wofsy, C

机构：

[1] NIAMS, Arthritis & Rheumatism Branch, NIH, Bethesda, MD 20892 USA

[2] Univ Calif Los Alamos Natl Lab, Los Alamos, NM USA

[3] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA

[4] Univ New Mexico, Dept Math, Albuquerque, NM 87131 USA

来源：

IMMUNOLOGY LETTERS | 1999年 / 68卷 / 01期

关键词：

IgE receptor; tyrosine phosphorylation; membrane receptors;

D O I：

10.1016/S0165-2478(99)00030-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The high affinity receptor for IgE (Fc epsilon RI), is one of a family of immunoreceptors whose antigen-induced clustering leads to a variety of cellular responses. The signaling pathways are enormously complex but by focusing on only the most initial steps, it is now possible to sketch plausible molecular models that relate the interaction of multivalent antigens with the receptor-bound IgE to the earliest cellular events. In this paper, we describe how we have combined quantitative experimentation and mathematical modeling to probe this system further. We also discuss some of the formidable challenges that remain before we can claim reasonably complete understanding of even these early events. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：53 / 57

页数：5

共 28 条

[1] COMPLETE STRUCTURE AND EXPRESSION IN TRANSFECTED CELLS OF HIGH-AFFINITY IGE RECEPTOR [J].