Noncultured Autologous Adipose-Derived Stem Cells Therapy for Chronic Radiation Injury

被引：63

作者：

Akita, Sadanori ^{[1
]}

Akino, Kozo ^{[1
]}

Hirano, Akiyoshi ^{[1
]}

Ohtsuru, Akira ^{[2
]}

Yamashita, Shunichi ^{[3
,4
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Plast & Reconstruct Surg, Nagasaki 8528501, Japan

[2] Nagasaki Univ Hosp, Takashi Nagai Mem Int Hibakusha Med Ctr, Nagasaki 8528501, Japan

[3] Nagasaki Univ, Sch Med, Atom Bomb Dis Inst, Nagasaki 8528501, Japan

[4] WHO, CH-1211 Geneva 27, Switzerland

来源：

STEM CELLS INTERNATIONAL | 2010年 / 2010卷

关键词：

TISSUE; TRANSPLANT;

D O I：

10.4061/2010/532704

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Increasing concern on chronic radiation injuries should be treated properly for life-saving improvement of wound management and quality of life. Recently, regenerative surgical modalities should be attempted with the use of noncultured autologous adipose-derived stem cells (ADSCs) with temporal artificial dermis impregnated and sprayed with local angiogenic factor such as basic fibroblast growth factor, and secondary reconstruction can be a candidate for demarcation and saving the donor morbidity. Autologous adipose-derived stem cells, together with angiogenic and mitogenic factor of basic fibroblast growth factor and an artificial dermis, were applied over the excised irradiated skin defect and tested for Patients who were uneventfully healed with minimal donor-site morbidity, which lasts more than 1.5 years.

引用

页数：8

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