Spinal Cord Injury: A Review of Current Therapy, Future Treatments, and Basic Science Frontiers

被引：279

作者：

Varma, Abhay K. ^{[1
]}

Das, Arabinda ^{[1
]}

Wallace, Gerald ^{[1
]}

Barry, John ^{[2
]}

Vertegel, Alexey A. ^{[2
]}

Ray, Swapan K. ^{[3
]}

Banik, Naren L. ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA

[2] Clemson Univ, Clemson, SC USA

[3] Univ S Carolina, Sch Med, Dept Pathol Microbiol & Immunol, Columbia, SC 29209 USA

来源：

NEUROCHEMICAL RESEARCH | 2013年 / 38卷 / 05期

关键词：

Spinal cord injury; Clinical; Preclinical; THYROTROPIN-RELEASING-HORMONE; PROMOTES FUNCTIONAL RECOVERY; FIBROBLAST-GROWTH-FACTOR; STEM-CELL THERAPY; ADULT RATS; OXIDATIVE STRESS; CONTROLLED-TRIAL; AXONAL GROWTH; UP-REGULATION; CYTOCHROME-C;

D O I：

10.1007/s11064-013-0991-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The incidence of acute and chronic spinal cord injury (SCI) in the United States is more than 10,000 per year, resulting in 720 cases per million persons enduring permanent disability each year. The economic impact of SCI is estimated to be more than 4 billion dollars annually. Preclinical studies, case reports, and small clinical trials suggest that early treatment may improve neurological recovery. To date, no proven therapeutic modality exists that has demonstrated a positive effect on neurological outcome. Emerging data from recent preclinical and clinical studies offer hope for this devastating condition. This review gives an overview of current basic research and clinical studies for the treatment of SCI.

引用

页码：895 / 905

页数：11

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