Impact of Intravenous Loop Diuretics on Outcomes of Patients Hospitalized with Acute Decompensated Heart Failure: Insights from the ADHERE Registry

被引：192

作者：

Peacock, W. Franklin ^{[2
]}

Costanzo, Maria Rosa

De Marco, Teresa ^{[3
]}

Lopatin, Margarita ^{[4
]}

Wynne, Janet ^{[4
]}

Mills, Roger M. ^{[4
]}

Emerman, Charles L. ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Emergency Med, Cleveland, OH 44109 USA

[2] Cleveland Clin Fdn, Dept Emergency Med, Cleveland, OH 44195 USA

[3] Univ Calif San Francisco, Div Cardiol, San Francisco, CA 94143 USA

[4] Scios Inc, Fremont, CA USA

来源：

CARDIOLOGY | 2009年 / 113卷 / 01期

关键词：

Diuretics; Acute Decompensated Heart Failure National Registry; Creatinine; Glomerular filtration rate; WORSENING RENAL-FUNCTION; LEFT-VENTRICULAR DYSFUNCTION; HIGH-DOSE FUROSEMIDE; MORTALITY; ACTIVATION; MANAGEMENT; RESISTANCE; THERAPY; GUIDELINES; DEATH;

D O I：

10.1159/000164149

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The optimal use of diuretics in decompensated heart failure remains uncertain. We analyzed data from the ADHERE registry to look at the impact of diuretic dosing. 62,866 patients receiving <160 mg and 19,674 patients >= 160 mg of furosemide were analyzed. The patients receiving the lower doses had a lower risk for in-hospital mortality, ICU stay, prolonged hospitalization, or adverse renal effects. These findings suggest that future studies should evaluate strategies for minimizing exposure to high doses of diuretics. Copyright (C) 2008 S. Karger AG, Basel

引用

页码：12 / 19

页数：8

共 32 条

[1] In-hospital mortality in patients with acute decompensated heart failure requiring intravenous vasoactive medications - An analysis from the Acute Decompensated Heart Failure National Registry (ADHERE) [J].

Abraham, WT ;

Adams, KF ;

Fonarow, GC ;

Costanzo, MR ;

Berkowitz, RL ;

LeJemtel, TH ;

Cheng, ML ;

Wynne, J .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2005, 46 (01) :57-64

[2] Characteristics and outcomes of patients hospitalized for heart failure in the United States: Rationale, design, and preliminary observations from the first 100,000, cases in the Acute Decompensated Heart Failure National Registry (ADHERE) [J].

Adams, KF ;

Fonarow, GC ;

Emerman, CL ;

LeJemtel, TH ;

Costanzo, MR ;

Abraham, WT ;

Berkowitz, RL ;

Galvao, M ;

Horton, DP .

AMERICAN HEART JOURNAL, 2005, 149 (02) :209-216

[3] Aldosteronism and peripheral blood mononuclear cell activation - A neuroendocrine-immune interface [J].

Ahokas, RA ;

Warrington, KJ ;

Gerling, IC ;

Sun, Y ;

Wodi, LA ;

Herring, PA ;

Lu, L ;

Bhattacharya, SK ;

Postlethwaite, AE ;

Weber, KT .

CIRCULATION RESEARCH, 2003, 93 (10) :E124-E135

[4] DOES ARREST REALLY DETER WIFE BATTERY - AN EFFORT TO REPLICATE THE FINDINGS OF THE MINNEAPOLIS-SPOUSE-ABUSE-EXPERIMENT [J].

BERK, RA ;

NEWTON, PJ .

AMERICAN SOCIOLOGICAL REVIEW, 1985, 50 (02) :253-262

[5] Relationship between heart failure treatment and development of worsening renal function among hospitalized patients [J].

Butler, J ;

Forman, DE ;

Abraham, WT ;

Gottlieb, SS ;

Loh, E ;

Massie, BM ;

O'Connor, CM ;

Rich, MW ;

Stevenson, LW ;

Wang, YF ;

Young, JB ;

Krumholz, HM .

AMERICAN HEART JOURNAL, 2004, 147 (02) :331-338

[6] Randomised trial of high-dose isosorbide dinitrate plus low-dose furosemide versus high-dose furosemide plus low-dose isosorbide dinitrate in severe pulmonary oedema [J].

Cotter, G ;

Metzkor, E ;

Kaluski, E ;

Faigenberg, Z ;

Miller, R ;

Simovitz, A ;

Shaham, O ;

Marghitay, D ;

Koren, M ;

Blatt, A ;

Moshkovitz, Y ;

Zaidenstein, R ;

Golik, A .

LANCET, 1998, 351 (9100) :389-393

[7] Increased toxicity of high-dose furosemide versus low-dose dopamine in the treatment of refractory congestive heart failure [J].

Cotter, G ;

Weissgarten, J ;

Metzkor, E ;

Moshkovitz, Y ;

Litinski, I ;

Tavori, U ;

Perry, C ;

Zaidenstein, R ;

Golik, A .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1997, 62 (02) :187-193

[8] Mechanisms and management of diuretic resistance in congestive heart failure [J].

De Bruyne, LKM .

POSTGRADUATE MEDICAL JOURNAL, 2003, 79 (931) :268-271

[9] Guidelines for acute decompensated heart failure treatment [J].

DiDomenico, RJ ;

Park, HY ;

Southworth, MR ;

Eyrich, HM ;

Lewis, RK ;

Finley, JM ;

Schumock, GT .

ANNALS OF PHARMACOTHERAPY, 2004, 38 (04) :649-660

[10] Diuretic use, progressive heart failure, and death in patients in the DIG study [J].

Domanski, M ;

Tian, X ;

Haigney, M ;

Pitt, B .

JOURNAL OF CARDIAC FAILURE, 2006, 12 (05) :327-332

← 1 2 3 4 →