Does urea denature hydrophobic interactions?

被引：120

作者：

Lee, ME ^{[1
]}

van der Vegt, NFA ^{[1
]}

机构：

[1] Max Planck Inst Polymer Res, D-55128 Mainz, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 15期

关键词：

D O I：

10.1021/ja058600r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It is generally accepted that clusters of hydrophobic moieties in water fall apart when urea is added in substantial amounts. We performed atomistic molecular dynamics simulations of hydrophobic solute pairs and found evidence that urea molecules act as glue" bridging these pairs thereby holding them together. The picture is quite general as it applies to aliphatic-aliphatic as well as aromatic-aromatic interactions. The implications of this finding on the role of urea as a protein denaturant are discussed. Copyright © 2006 American Chemical Society."

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页码：4948 / 4949

页数：2

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