Changes in Markers of Ovarian Reserve After Laparoscopic Ovarian Cystectomy

Study Objective: This study was conducted to determine the changes in ovarian reserve markers after laparoscopic ovarian cystectomy (LOC). Design: Prospective cohort study (Canadian Task Force classification II-2). Setting: University teaching hospital. Patients: Fifty 50 patients who underwent LOC were prospectively examined to determine the changes in serum markers of ovarian reserve, starting from 1 month before and 3 months after consecutive operations. Interventions: Changes in serum markers were compared between the following groups: endometrioma cysts (n = 26) versus nonendometrioma cysts (n = 24), unilateral cystectomy (n = 38) versus bilateral cystectomy (n = 12), and bilateral endometrioma extirpation (n = 10) versus other cystectomy operations (n = 40). Measurements and Main Results: A significant change was noticed between the preoperative and postoperative antimullerian hormone (AMH) levels (2.67 +/- 2.67 ng/mL vs 1.84 +/- 1.72 ng/mL, p < .0001). Serum AMH levels were found to be significantly decreased in endometrioma (p = .002), nonendometrioma (p = .019), unilateral cystectomy (p = .001), bilateral cystectomy (p = .005), bilateral endometrioma (p = .011), and cysts other than bilateral endometrioma (p = .000) groups. Conclusion: The ovarian reserve was found to be diminished after LOC regardless of the presence of endometrioma that could be distinguishable by serum AMH levels. (C) 2015 AAGL. All rights reserved.