Recurrent spontaneous arterial dissections - Risk in familial versus nonfamilial disease

被引:89
作者
Schievink, WI
Mokri, B
Piepgras, DG
Kuiper, JD
机构
[1] MAYO CLIN & MAYO FDN, DEPT NEUROL, ROCHESTER, MN 55905 USA
[2] MAYO CLIN & MAYO FDN, DEPT HLTH SCI RES, ROCHESTER, MN 55905 USA
关键词
aneurysm; cerebrovascular disorders; dissection; genetics;
D O I
10.1161/01.STR.27.4.622
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose Among patients with spontaneous cervical artery dissections, the risk of recurrent arterial dissection is relatively low at 1% per year, but this risk may be higher for patients with a family history of arterial dissections. We compared the risk of a recurrent arterial dissection in patients with familial versus nonfamilial disease. Methods Long-term follow-up was established in 200 patients (104 women and 96 men with a mean age of 44.9 years) with spontaneous cervical artery dissections evaluated at a single institution between 1970 and 1990. Results Among the 200 patients, 10 (5%) were identified who had a family history of spontaneous arterial dissections. In a multivariate analysis, family history was the only significant variable associated with the risk of recurrent dissection (chi(2)=15.51; P=.0001). A recurrent arterial dissection was identified in 5 (50%) of the 10 patients with familial disease compared with 11 (5.8%) of the 190 patients with nonfamilial disease, with an estimated relative risk of 6.3 (95% confidence interval, 2.2 to 18.3; P=.0007). Conclusions Among patients with spontaneous cervical artery dissections, a family history of arterial dissection is an important risk factor for the development of a recurrent arterial dissection.
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页码:622 / 624
页数:3
相关论文
共 10 条
[1]   FAMILIAL AGGREGATION OF CERVICAL ARTERY DISSECTION AND CEREBRAL ANEURYSM [J].
MAJAMAA, K ;
PORTIMOJARVI, H ;
SOTANIEMI, KA ;
MYLLYLA, VV .
STROKE, 1994, 25 (08) :1704-1705
[2]   FAMILIAL OCCURRENCE OF SPONTANEOUS DISSECTION OF THE INTERNAL CAROTID-ARTERY [J].
MOKRI, B ;
PIEPGRAS, DG ;
WIEBERS, DO ;
HOUSER, OW .
STROKE, 1987, 18 (01) :246-251
[3]  
MOKRI B, 1994, ANN NEUROL, V36, P263
[4]   FAMILIAL OCCURRENCE OF DISSECTION OF THE CERVICAL ARTERIES [J].
NEAU, JP ;
MASSON, C ;
VANDERMARCQ, P ;
DUMAS, P ;
LEVILLAIN, P ;
TANTOT, AM ;
MASSON, M ;
GIL, R .
CEREBROVASCULAR DISEASES, 1995, 5 (04) :310-312
[5]  
PETIT H, 1983, J NEURORADIOLOGY, V10, P15
[6]   A FAMILIAL SYNDROME OF ARTERIAL DISSECTIONS WITH LENTIGINOSIS [J].
SCHIEVINK, WI ;
MICHELS, VV ;
MOKRI, B ;
PIEPGRAS, DG ;
PERRY, HO .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (09) :576-579
[7]   FAMILIAL AORTO-CERVICOCEPHALIC ARTERIAL DISSECTIONS AND CONGENITALLY BICUSPID AORTIC-VALVE [J].
SCHIEVINK, WI ;
MOKRI, B .
STROKE, 1995, 26 (10) :1935-1940
[8]   RECURRENT SPONTANEOUS CERVICAL-ARTERY DISSECTION [J].
SCHIEVINK, WI ;
MOKRI, B ;
OFALLON, WM .
NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (06) :393-397
[9]  
SOMIO S, 1993, J AM SOC NEPHROL, V4, P1371
[10]  
VARANI E, 1988, MED-RIV ENC MED ITAL, V8, P293