Agranulocytosis associated with lamotrigine in a patient with low-grade glioma

被引：14

作者：

Fadul, CE

Meyer, LP

Jobst, BC

Cornell, CJ

Lewis, LD

机构：

[1] Dartmouth Coll Sch Med, Dartmouth Hitchcock Med Ctr, Dept Med, Hematol Oncol Sect, Lebanon, NH 03756 USA

[2] Dartmouth Coll Sch Med, Dartmouth Hitchcock Med Ctr, Dept Med, Neurol Sect, Lebanon, NH USA

[3] Dartmouth Coll Sch Med, Dartmouth Hitchcock Med Ctr, Dept Med, Clin Pharmacol Sect, Lebanon, NH USA

来源：

EPILEPSIA | 2002年 / 43卷 / 02期

关键词：

agranulocytosis; lamotrigine; seizures; glioma; chemotherapy;

D O I：

10.1046/j.1528-1157.2002.31801.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose: To report agranulocytosis associated with lamotrigine (LTG) in a patient with a brain tumor. Methods: A 59-year-old woman with a low-grade glioma and difficult-to-control partial seizures developed agranulocytosis between 9 and 14 weeks after starting LTG. The patient underwent chemotherapy 2 years previously. Results: After stopping LTG, the agranulocytosis persisted for 9 days despite 7 days of granulocyte-colony-stimulating factor (G-CSF), and ultimately resolved. Conclusions: In this case, the use of LTG was associated with the development of agranulocytosis, and it is likely that this association was causative.

引用

页码：199 / 200

页数：2

共 9 条

[1]

*BRIT MED ASS, 2001, BRIT NAT FORM, V42, P229

[2]

LAMOTRIGINE [J].