Estimation of insulin sensitivity in children: methods, measures and controversies

被引：49

作者：

Brown, Rebecca J. ^{[1
]}

Yanovski, Jack A. ^{[2
]}

机构：

[1] NIDDK, Diabet Endocrinol & Obes Branch, Bethesda, MD 20892 USA

[2] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Growth & Obes, Program Dev Endocrinol & Genet, NIH,DHHS, Bethesda, MD 20892 USA

来源：

PEDIATRIC DIABETES | 2014年 / 15卷 / 03期

关键词：

FSIGT; glucose clamp technique; glucose tolerance; HOMA; insulin sensitivity; QUICKI; surrogate measures; GLUCOSE-TOLERANCE TEST; BETA-CELL FUNCTION; DEPENDENT DIABETES-MELLITUS; OBESE ADOLESCENT BOYS; MINIMAL MODEL; INTRAVENOUS GLUCOSE; OVERWEIGHT CHILDREN; AFRICAN-AMERICAN; FATTY-ACID; IN-VIVO;

D O I：

10.1111/pedi.12146

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin resistance is defined as a state where insulin produces a diminished biological response, primarily in its capacity as a glucose-regulating hormone. Insulin resistance is commonly diagnosed by pediatric clinicians, but is rarely measured directly in children or adolescents. This review provides an overview of the techniques that can be used to assess insulin sensitivity in children, summarizing the methods involved, the assumptions, pitfalls, and appropriate uses of each technique, as well as their validation and reproducibility in pediatric samples.

引用

页码：151 / 161

页数：11

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