Synthesis of oligonucleotide-peptide conjugates using hydrazone chemical ligation

被引：29

作者：

Ollivier, N

Olivier, C

Gouyette, C

Huynh-Dinh, T

Gras-Masse, H

Melnyk, O

机构：

[1] CNRS, Inst Biol Lille, UMR 8525, F-59021 Lille, France

[2] Inst Pasteur, URA 2128, F-75724 Paris, France

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(01)02315-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An oligonucleotide was functionalized on the solid-phase by a tartaramide moiety, which could be converted efficiently in solution into a glyoxylyl group following a mild periodic oxidation. The glyoxylyl-oligonucleotide was found to be very stable upon storage and was successfully engaged in hydrazone ligation with an alpha-hydrazino acetyl peptide. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：997 / 999

页数：3

共 16 条

[1] A novel lipophilic glyoxylic acid derivative for the lipidation of peptides using salt-free hydrazone ligation [J].