Nucleation control in solution mediated polymorphic phase transformations: The case of 2,6-dihydroxybenzoic acid

被引：106

作者：

Davey, RJ ^{[1
]}

Blagden, N ^{[1
]}

Righini, S ^{[1
]}

Alison, H ^{[1
]}

Ferrari, ES ^{[1
]}

机构：

[1] UMIST, Dept Chem Engn, Crystals Colloids & Interfaces Grp, Manchester M60 1QD, Lancs, England

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2002年 / 106卷 / 08期

关键词：

D O I：

10.1021/jp013044i

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This contribution describes the kinetics of the solution mediated phase transformation between forms I and 2 of dihydroxybenzoic acid. It is shown how a combination of kinetic, morphological, and modeling data can be used to give a full description of the rate-determining process in such a trails formation. Surprisingly, secondary nucleation is found to dominate the kinetic processes. Such a phenomenon is well-known in continuous crystallization but is reported here for the first time in a polymorphic phase trans formation. This observation has significant consequences for process and product control in the pharmaceutical and specialty chemicals industries.

引用

页码：1954 / 1959

页数：6

共 17 条

[1]

Bernstein J, 1999, ANGEW CHEM INT EDIT, V38, P3440, DOI 10.1002/(SICI)1521-3773(19991203)38:23<3440::AID-ANIE3440>3.0.CO

[2]

2-#

[3] Disappearing polymorphs and the role of reaction by-products: the case of sulphathiazole [J].

Blagden, N ;

Davey, RJ ;

Rowe, R ;

Roberts, R .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1998, 172 (1-2) :169-177

[4]

Blagden N, 1999, CHEM BRIT, V35, P44

[5] Crystal polymorphism as a probe for molecular self-assembly during nucleation from solutions: The case of 2,6-dihydroxybenzoic acid [J].

Davey, RJ ;

Blagden, N ;

Righini, S ;

Alison, H ;

Quayle, MJ ;

Fuller, S .

CRYSTAL GROWTH & DESIGN, 2001, 1 (01) :59-65

[6] RATE CONTROLLING PROCESSES IN SOLVENT-MEDIATED PHASE-TRANSFORMATIONS [J].

DAVEY, RJ ;

CARDEW, PT ;

MCEWAN, D ;

SADLER, DE .

JOURNAL OF CRYSTAL GROWTH, 1986, 79 (1-3) :648-653

[7] A SOLVENT MEDIATED PHASE-TRANSFORMATION IN AN AQUEOUS SUSPENSION OF AN AZO DISPERSE DYE [J].

DAVEY, RJ ;

RICHARDS, J .

JOURNAL OF CRYSTAL GROWTH, 1985, 71 (03) :597-601

[8]

DAVEY RJ, 2000, MOL CRYSALLISERS INT

[9]

DAVEY RJ, 1981, CURRENT TOPICS MAT S, V8, pCH6

[10] GAMMA-RESORCYCLIC ACID, ITS MONOHYDRATE AND ITS PYRIDINIUM COMPLEX [J].

GDANIEC, M ;

GILSKI, M ;

DENISOV, GS .

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1994, 50 :1622-1626

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