A KRAB Domain Zinc Finger Protein in Imprinting and Disease

被引：21

作者：

Hirasawa, Ryutaro

Feil, Robert ^{[1
]}

机构：

[1] CNRS, Inst Mol Genet, F-34293 Montpellier, France

来源：

DEVELOPMENTAL CELL | 2008年 / 15卷 / 04期

关键词：

D O I：

10.1016/j.devcel.2008.09.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The monoallelic expression of imprinted genes is regulated by DNA methylation marks that originate from the oocyte or sperm. Li et al. (2008) show in this issue of Developmental Cell that the KRAB zinc finger protein Zfp57 contributes to the embryonic maintenance of these imprints. At one locus, Zfp57 is also involved in imprint establishment. These findings provide a mechanistic interpretation for Mackay et al.'s recently reported ZFP57 mutations in patients with transient neonatal diabetes.

引用

收藏

页码：487 / 488

页数：2

相关论文

共 10 条

[1] Stochastic imprinting in the progeny of Dnmt3L-/- females [J].

Arnaud, P ;

Hata, K ;

Kaneda, M ;

Li, E ;

Sasaki, H ;

Feil, R ;

Kelsey, G .

HUMAN MOLECULAR GENETICS, 2006, 15 (04) :589-598

[2] Convergent evolution of genomic imprinting in plants and mammals [J].

Feil, Robert ;

Berger, Frederic .

TRENDS IN GENETICS, 2007, 23 (04) :192-199

[3] Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development [J].

Hirasawa, Ryutaro ;

Chiba, Hatsune ;

Kaneda, Masahiro ;

Tajima, Shoji ;

Li, En ;

Jaenisch, Rudolf ;

Sasaki, Hiroyuki .

GENES & DEVELOPMENT, 2008, 22 (12) :1607-1616

[4] Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting [J].

Kaneda, M ;

Okano, M ;

Hata, K ;

Sado, T ;

Tsujimoto, N ;

Li, E ;

Sasaki, H .

NATURE, 2004, 429 (6994) :900-903

[5] A Maternal-Zygotic Effect Gene, Zfp57, Maintains Both Maternal and Paternal Imprints [J].

Li, Xiajun ;

Ito, Mitsuteru ;

Zhou, Fen ;

Youngson, Neil ;

Zuo, Xiaopan ;

Leder, Philip ;

Ferguson-Smith, Anne C. .

DEVELOPMENTAL CELL, 2008, 15 (04) :547-557

[6] Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57 [J].

Mackay, Deborah J. G. ;

Callaway, Jonathan L. A. ;

Marks, Sophie M. ;

White, Helen E. ;

Acerini, Carlo L. ;

Boonen, Susanne E. ;

Dayanikli, Pinar ;

Firth, Helen V. ;

Goodship, Judith A. ;

Haemers, Andreas P. ;

Hahnemann, Johanne M. D. ;

Kordonouri, Olga ;

Masoud, Ahmed F. ;

Oestergaard, Elsebet ;

Storr, John ;

Ellard, Sian ;

Hattersley, Andrew T. ;

Robinson, David O. ;

Temple, I. Karen .

NATURE GENETICS, 2008, 40 (08) :949-951

[7] PGC7/Stella protects against DNA demethylation in early embryogenesis [J].

Nakamura, Toshinobu ;

Arai, Yoshikazu ;

Umehara, Hiroki ;

Masuhara, Masaaki ;

Kimura, Tohru ;

Taniguchi, Hisaaki ;

Sekimoto, Toshihiro ;

Ikawa, Masahito ;

Yoneda, Yoshihiro ;

Okabe, Masaru ;

Tanaka, Satoshi ;

Shiota, Kunio ;

Nakano, Toru .

NATURE CELL BIOLOGY, 2007, 9 (01) :64-U81

[8] PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse [J].

Pannetier, Maelle ;

Julien, Eric ;

Schotta, Gunnar ;

Tardat, Mathieu ;

Sardet, Claude ;

Jenuwein, Thomas ;

Feil, Robert .

EMBO REPORTS, 2008, 9 (10) :998-1005

[9] Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth [J].

Varrault, Annie ;

Gueydan, Charlotte ;

Delalbre, Annie ;

Bellmann, Anja ;

Houssami, Souheir ;

Aknin, Cindy ;

Severac, Dany ;

Chotard, Laetitia ;

Kahli, Malik ;

Le Digarcher, Anne ;

Pavlidis, Paul ;

Journot, Laurent .

DEVELOPMENTAL CELL, 2006, 11 (05) :711-722

[10] The Kruppel-associated box repressor domain can trigger de Novo promoter methylation during mouse early embryogenesis [J].

Wiznerowicz, Maciej ;

Jakobsson, Johan ;

Szulc, Jolanta ;

Liao, Shunyao ;

Quazzola, Alexandra ;

Beermann, Friedrich ;

Aebischer, Patrick ;

Trono, Didier .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (47) :34535-34541