Arg-gingipain inhibition and anti-bacterial activity selective for Porphyromonas gingivalis by malabaricone C

被引：24

作者：

Shinohara, C ^{[1
]}

Mori, S ^{[1
]}

Ando, T ^{[1
]}

Tsuji, T ^{[1
]}

机构：

[1] Sagami Chem Res Ctr, Sagamihara, Kanagawa 2290012, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1999年 / 63卷 / 08期

关键词：

malabaricone C; Arg-gingipain; Porphyromonas gingivalis; periodontal disease; Myristica fragrans;

D O I：

10.1271/bbb.63.1475

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Effects of malabaricon C, isolated from nutmeg (Myristica fragrans), on Arg-gingipain activity and growth of several kinds of anaerobic and aerobic microorganisms were investigated. Malabaricone C irreversibly inhibited Arg-gingipain by 50% at a concentration of 0.7 mu g/ml and selectively suppressed Porphyromomas gingivalis growth.

引用

页码：1475 / 1477

页数：3

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