Human mutation - blame (mostly) men

被引:12
作者
Ellegren, H [1 ]
机构
[1] Uppsala Univ, Evolutionary Biol Ctr, Dept Evolutionary Biol, SE-75236 Uppsala, Sweden
关键词
D O I
10.1038/ng0502-9
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The relative contribution of mothers and fathers to mutation can be studied by evolutionary analysis of sex-linked DNA sequences. A new study shows that mutations occur in men at a rate five times of that in women, lending support to the idea of 'male-driven evolution'.
引用
收藏
页码:9 / 10
页数:2
相关论文
共 15 条
[1]   Unexpectedly similar rates of nucleotide substitution found in male and female hominids [J].
Bohossian, HB ;
Skaletsky, H ;
Page, DC .
NATURE, 2000, 406 (6796) :622-625
[2]   The origins patterns and implications of human spontaneous mutation [J].
Crow, JF .
NATURE REVIEWS GENETICS, 2000, 1 (01) :40-47
[3]   Heterogeneous mutation processes in human microsatellite DNA sequences [J].
Ellegren, H .
NATURE GENETICS, 2000, 24 (04) :400-402
[4]  
HALDANE JBS, 1947, ANN EUGENIC, V13, P262
[5]   Sex biases in the mutation rate [J].
Hurst, LD ;
Ellegren, H .
TRENDS IN GENETICS, 1998, 14 (11) :446-452
[6]   Initial sequencing and analysis of the human genome [J].
Lander, ES ;
Int Human Genome Sequencing Consortium ;
Linton, LM ;
Birren, B ;
Nusbaum, C ;
Zody, MC ;
Baldwin, J ;
Devon, K ;
Dewar, K ;
Doyle, M ;
FitzHugh, W ;
Funke, R ;
Gage, D ;
Harris, K ;
Heaford, A ;
Howland, J ;
Kann, L ;
Lehoczky, J ;
LeVine, R ;
McEwan, P ;
McKernan, K ;
Meldrim, J ;
Mesirov, JP ;
Miranda, C ;
Morris, W ;
Naylor, J ;
Raymond, C ;
Rosetti, M ;
Santos, R ;
Sheridan, A ;
Sougnez, C ;
Stange-Thomann, N ;
Stojanovic, N ;
Subramanian, A ;
Wyman, D ;
Rogers, J ;
Sulston, J ;
Ainscough, R ;
Beck, S ;
Bentley, D ;
Burton, J ;
Clee, C ;
Carter, N ;
Coulson, A ;
Deadman, R ;
Deloukas, P ;
Dunham, A ;
Dunham, I ;
Durbin, R ;
French, L .
NATURE, 2001, 409 (6822) :860-921
[7]   Local similarity in evolutionary rates extends over whole chromosomes in human-rodent and mouse-rat comparisons: Implications for understanding the mechanistic basis of the male mutation bias [J].
Lercher, MJ ;
Williams, EJB ;
Hurst, LD .
MOLECULAR BIOLOGY AND EVOLUTION, 2001, 18 (11) :2032-2039
[8]   Strong male-driven evolution of DNA sequences in humans and apes [J].
Makova, KD ;
Li, WH .
NATURE, 2002, 416 (6881) :624-626
[9]   Evidence for a selectively favourable reduction in the mutation rate of the X chromosome [J].
McVean, GT ;
Hurst, LD .
NATURE, 1997, 386 (6623) :388-392
[10]   MALE-DRIVEN MOLECULAR EVOLUTION - A MODEL AND NUCLEOTIDE-SEQUENCE ANALYSIS [J].
MIYATA, T ;
HAYASHIDA, H ;
KUMA, K ;
MITSUYASU, K ;
YASUNAGA, T .
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1987, 52 :863-867