Synthesis of some new 1,4-benzothiazine and 1,5-benzothiazepine tricyclic derivatives with structural analogy with TIBO and their screening for anti-HIV activity

被引：62

作者：

Grandolini, G ^{[1
]}

Perioli, L ^{[1
]}

Ambrogi, V ^{[1
]}

机构：

[1] Univ Perugia, Ist Chim & Tecnol Farmaco, I-06123 Perugia, Italy

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1999年 / 34卷 / 09期

关键词：

1,4-benzothiazine and 1,5-benzothiazepine derivatives; anti-HIV-1; activity; non-nucleoside reverse transcriptase inhibitor (NNRTI);

D O I：

10.1016/S0223-5234(99)00223-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several new tricyclic derivatives with structural analogy to TIBO were prepared starting from properly substituted 1,4-benzothiazines and 1,5-benzothiazepine. All synthesized compounds were submitted to screenings for in vitro anti-HIV-1 activity. Only two compounds showed moderate activity. (C) 1999 Editions scientifiques et medicales Elsevier SAS.

引用

页码：701 / 709

页数：9

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