Insulin-like growth factor I - An attractive option for chronic heart failure?

被引：5

作者：

Donath, MY ^{[1
]}

Zapf, J ^{[1
]}

机构：

[1] Univ Zurich Hosp, Dept Med, Div Endocrinol & Diabet, CH-8091 Zurich, Switzerland

来源：

DRUGS & AGING | 1999年 / 15卷 / 04期

关键词：

D O I：

10.2165/00002512-199915040-00001

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Chronic congestive heart failure is a syndrome with a poor prognosis. Currently, the only therapy providing the possibility of long term survival is heart transplantation. Therefore, new therapeutic strategies continue to be investigated. One such new approach may be the application of recombinant human insulin-like growth factor (IGF)-1. IGF-1 has both acute and long term cardiovascular effects. Acute administration of IGF-1 resulted in a reduction in afterload and positive inotropic effects in patients with heart failure. In vitro and animal studies have demonstrated that IGF-1 can stimulate myofibril formation. In addition, IGF-1 administration has beneficial metabolic effects. The benefits of prolonged IGF-1 therapy have yet to be investigated.

引用

页码：251 / 254

页数：4

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