Haplotype Analysis of the PARK 11 Gene, GIGYF2, in Sporadic Parkinson's Disease

被引：19

作者：

Sutherland, Greg T. ^{[1
]}

Siebert, Gerhard A. ^{[1
]}

Newman, Jeremy R. B. ^{[1
]}

Silburn, Peter A. ^{[1
,2
]}

Boyle, Richard S. ^{[3
]}

O'Sullivan, Johr. D. ^{[4
]}

Mellick, George D. ^{[1
,3
,4
]}

机构：

[1] Griffith Univ, Sch Biomol & Phys Sci, Eskitis Inst Cell & Mol Therapies, Brisbane, Qld 4111, Australia

[2] Univ Queensland, Sch Med, UQ Ctr Clin Res, Brisbane, Qld, Australia

[3] Princess Alexandra Hosp, Dept Neurol, Brisbane, Qld 4102, Australia

[4] Royal Brisbane & Womens Hosp, Dept Neurol, Brisbane, Qld, Australia

来源：

MOVEMENT DISORDERS | 2009年 / 24卷 / 03期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Parkinson's disease; PD-related genes; association; ENVIRONMENT INTERACTIONS; ASSOCIATION; EXPOSURES; DOPAMINE;

D O I：

10.1002/mds.22427

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence disease risk. Recently, mutations were described in the gene, GIGYF2 (TNRC15), located at the PARK11 locus (2q37.1). Here, we use a haplotype tagging approach to examine common variation in the GIGYF2 gene and PD risk. PD cases (n = 568) and age and gender-matched control subjects (n = 568) were recruited from three specialist movement disorder clinics in Brisbane (Australia) and the Australian electoral roll. Twelve tagging SNPs were assessed in all subjects and haplotype and genotype associations were explored. Overall our findings suggest that common genetic variants of GIGYF2 do not significantly affect sporadic PD risk in Australian Caucasians. (C) 2008 Movement Disorder Society

引用

页码：449 / 452

页数：4

共 21 条

[1]

BARBEAU A, 1987, PARKINSONS DIS ADV N, P299

[2] Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection [J].

Chung, CY ;

Seo, H ;

Sonntag, KC ;

Brooks, A ;

Lin, L ;

Isacson, O .

HUMAN MOLECULAR GENETICS, 2005, 14 (13) :1709-1725

[3] Efficiency and power in genetic association studies [J].

de Bakker, PIW ;

Yelensky, R ;

Pe'er, I ;

Gabriel, SB ;

Daly, MJ ;

Altshuler, D .

NATURE GENETICS, 2005, 37 (11) :1217-1223

[4] Environmental risk factors for Parkinson's disease and parkinsonism: the Geoparkinson study [J].

Dick, F. D. ;

De Palma, G. ;

Ahmadi, A. ;

Scott, N. W. ;

Prescott, G. J. ;

Bennett, J. ;

Semple, S. ;

Dick, S. ;

Counsell, C. ;

Mozzoni, P. ;

Haites, N. ;

Wettinger, S. Bezzina ;

Mutti, A. ;

Otelea, M. ;

Seaton, A. ;

Soederkvist, P. ;

Felice, A. .

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 2007, 64 (10) :666-672

[5] Interaction between genes and environment in neurodegenerative diseases [J].

Elbaz, Alexis ;

Dufouil, Carole ;

Alperovitch, Annick .

COMPTES RENDUS BIOLOGIES, 2007, 330 (04) :318-328

[6] Epidemiologic studies of environmental exposures in Parkinson's disease [J].

Elbaz, Alexis ;

Tranchant, Christine .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2007, 262 (1-2) :37-44

[7] Genome-wide genotyping in Parkinson's disease and neurologically normal controls:: first stage analysis and public release of data [J].

Fung, Hon-Chung ;

Scholz, Sonja ;

Matarin, Mar ;

Simon-Sanchez, Javier ;

Hernandez, Dena ;

Britton, Angela ;

Gibbs, J. Raphael ;

Langefeld, Carl ;

Stiegert, Matt L. ;

Schymick, Jennifer ;

Okun, Michael S. ;

Mandel, Ronald J. ;

Fernandez, Hubert H. ;

Foote, Kelly D. ;

Rodriguez, Ramon L. ;

Peckham, Elizabeth ;

De Vrieze, Fabienne Wavrant ;

Gwinn-Hardy, Katrina ;

Hardy, John A. ;

Singleton, Andrew .

LANCET NEUROLOGY, 2006, 5 (11) :911-916

[8] Test-retest repeatability of self-reported environmental exposures in Parkinson's disease cases and healthy controls [J].

Gartner, CE ;

Battistutta, D ;

Dunne, MP ;

Silburn, PA ;

Mellick, GD .

PARKINSONISM & RELATED DISORDERS, 2005, 11 (05) :287-295

[9] Diagnostic criteria for Parkinson disease [J].

Gelb, DJ ;

Oliver, E ;

Gilman, S .

ARCHIVES OF NEUROLOGY, 1999, 56 (01) :33-39

[10] The International HapMap Project [J].

Gibbs, RA ;

Belmont, JW ;

Hardenbol, P ;

Willis, TD ;

Yu, FL ;

Yang, HM ;

Ch'ang, LY ;

Huang, W ;

Liu, B ;

Shen, Y ;

Tam, PKH ;

Tsui, LC ;

Waye, MMY ;

Wong, JTF ;

Zeng, CQ ;

Zhang, QR ;

Chee, MS ;

Galver, LM ;

Kruglyak, S ;

Murray, SS ;

Oliphant, AR ;

Montpetit, A ;

Hudson, TJ ;

Chagnon, F ;

Ferretti, V ;

Leboeuf, M ;

Phillips, MS ;

Verner, A ;

Kwok, PY ;

Duan, SH ;

Lind, DL ;

Miller, RD ;

Rice, JP ;

Saccone, NL ;

Taillon-Miller, P ;

Xiao, M ;

Nakamura, Y ;

Sekine, A ;

Sorimachi, K ;

Tanaka, T ;

Tanaka, Y ;

Tsunoda, T ;

Yoshino, E ;

Bentley, DR ;

Deloukas, P ;

Hunt, S ;

Powell, D ;

Altshuler, D ;

Gabriel, SB ;

Qiu, RZ .

NATURE, 2003, 426 (6968) :789-796

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