Glycolysis and oxidtion enzyme activity in rat brain during insulin-induced hypoglycemia against the background of alloxan-induced diabetes mellitus

被引：9

作者：

Telushkin, PK ^{[1
]}

Nozdrachev, AD ^{[1
]}

Potapov, PP ^{[1
]}

Medvedeva, NB ^{[1
]}

Stel'makh, AY ^{[1
]}

机构：

[1] St Petersburg State Univ, Yaroslavl State Med Acad, St Petersburg, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2005年 / 140卷 / 06期

关键词：

brain; insulin-induced hypoglycemia; alloxan diabetes; glycolysis; energy metabolism;

D O I：

10.1007/s10517-006-0057-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Insulin-induced hypoglycemic coma in animals with alloxan diabetes was observed at a higher basal glucose level in the blood compared to healthy animals. It was associated with inhibition of glycolysis and glycogenolysis and decreased activities of succinate dehydrogenase and glutamate dehydrogenase in the cerebral hemispheres and brainstem.

引用

页码：695 / 697

页数：3

共 10 条

[1] CNS energy metabolism as related to function [J].

Ames, A .

BRAIN RESEARCH REVIEWS, 2000, 34 (1-2) :42-68

[2] HYPOGLYCEMIA - BRAIN NEUROCHEMISTRY AND NEUROPATHOLOGY [J].

AUER, RN ;

SIESJO, BK .

BAILLIERES CLINICAL ENDOCRINOLOGY AND METABOLISM, 1993, 7 (03) :611-625

[3]

Balabolkin M. J., 2000, DIABETOLOGY

[4] DOES IMPAIRMENT OF ENERGY-METABOLISM RESULT IN EXCITOTOXIC NEURONAL DEATH IN NEURODEGENERATIVE ILLNESSES [J].

BEAL, MF .

ANNALS OF NEUROLOGY, 1992, 31 (02) :119-130

[5]

LIPTON P, 1991, Society for Neuroscience Abstracts, V17, P1155

[6] Effect of insulin-induced hypoglycemia on cytoskeleton-bound and cytosolic phosphofructokinase and the levels of glucose 1,6-bisphosphate in rat brain [J].

Magen, A ;

KorenSchwartzer, N ;

ChenZion, M ;

Beitner, R .

BIOCHEMICAL AND MOLECULAR MEDICINE, 1995, 56 (02) :94-98

[7] Cellular mechanisms of brain energy metabolism - Relevance to functional brain imaging and to neurodegenerative disorders [J].

Magistretti, PJ ;

Pellerin, L .

NEUROBIOLOGY OF ALZHEIMER'S DISEASE, 1996, 777 :380-387

[8]

PANIN LE, 1982, VOP MED KHIM, V28, P26

[9]

Prokhorova M. I., 1982, METHODS BIOCH STUDIE

[10]

Telushkin P. K., 1999, Uspekhi Fiziologicheskikh Nauk, V30, P14

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