Chitosan gel beads as drug carriers 2. Release of 8-hydroxy-7-iodoquinoline-5-sulfonic acid and 2,5-dihydroxybenzenesulfonic acid

被引：12

作者：

Koseva, N

Manolova, N ^{[1
]}

Markova, N

Radoucheva, T

Rashkov, I

机构：

[1] Bulgarian Acad Sci, Inst Polymer, BG-1113 Sofia, Bulgaria

[2] Bulgarian Acad Sci, Inst Microbiol, BG-1113 Sofia, Bulgaria

来源：

POLYMER BULLETIN | 1999年 / 43卷 / 01期

关键词：

Chitosan; Release Rate; Drug Release; Glutaraldehyde; Acidic Medium;

D O I：

10.1007/s002890050539

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

It is shown that chitosan gel beads are suitable carriers of 8-hydroxy-7-iodoquinoline-5-sulfonic acid (SQ) and 2,5-dihydroxybenzenesulfonic acid (DHBSA)- substances applied in medicine. Drug release has been investigated with respect to the nature of the crosslinking agent (epichlorohydrin or glutaraldehyde) and pH of the medium. Considerable differences in the release rate of DHBSA and SQ have been found. The total amount of the desorbed SQ, as well as the release rate of the drug depends on pH of the medium - they decrease from alkaline to acidic medium. The antimicrobial and antimycotic activity of the loaded with SQ beads is demonstrated.

引用

页码：101 / 107

页数：7

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