BACE1 Levels Correlate with Phospho-Tau Levels in Human Cerebrospinal Fluid

被引：25

作者：

Barao, Soraia ^{[1
,2
,3
,4
]}

Zhou, Lujia ^{[1
,2
,3
,4
]}

Adamczuk, Katarzyna ^{[5
]}

Vanhoutvin, Tine ^{[1
,2
,3
,4
]}

van Leuven, Fred ^{[7
]}

Demedts, David ^{[7
]}

Vijverman, Anne-Catherine ^{[8
]}

Bossuyt, Xavier ^{[6
]}

Vandenberghe, Rik ^{[5
,8
]}

De Strooper, Bart ^{[1
,2
,3
,4
]}

机构：

[1] VIB Ctr Biol Dis, Louvain, Belgium

[2] KULeuven, Ctr Human Genet, B-3000 Louvain, Belgium

[3] KULeuven, LIND, B-3000 Louvain, Belgium

[4] Univ Hosp, Louvain, Belgium

[5] KULeuven, Lab Cognit Neurol, Dept Neurol, B-3000 Louvain, Belgium

[6] KULeuven, Expt Immunol Lab, Dept Microbiol & Immunol, B-3000 Louvain, Belgium

[7] KULeuven, Lab Expt Genet & Transgenesis, B-3000 Louvain, Belgium

[8] Univ Hosp Leuven, Dept Neurol, Louvain, Belgium

来源：

CURRENT ALZHEIMER RESEARCH | 2013年 / 10卷 / 07期

关键词：

Alzheimer's disease; BACE1; biomarker; human CSF; neurodegeneration; sandwich ELISA; AMYLOID PRECURSOR PROTEIN; BETA-SECRETASE ACTIVITY; ALZHEIMERS-DISEASE; NEUROFIBRILLARY PATHOLOGY; MARKER; POPULATION; EXPRESSION; COMPLEX;

D O I：

10.2174/15672050113109990138

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Previous studies have investigated the activity and protein levels of BACE1, the beta-secretase, in the brain and cerebrospinal fluid (CSF) of Alzheimer's disease (AD) patients, however, results remain contradictory. We present here a highly specific and sensitive BACE1 ELISA, which allows measuring accurately BACE1 levels in human samples. We find that BACE1 levels in CSF of AD patients and other neurological disorder (OND) patients are slightly increased when compared to those of a non-neurological disorder control group (NND). BACE1 levels in CSF were well correlated with total-tau and hyperphosphorylated tau levels in the CSF, suggesting that the recorded alterations in BACE1 levels correlate with cell death and neurodegeneration.

引用

页码：671 / 678

页数：8

共 41 条

[41] Inhibition of β-Secretase in Vivo via Antibody Binding to Unique Loops (D and F) of BACE1 [J].

Zhou, Lujia ;

Chavez-Gutierrez, Lucia ;

Bockstael, Katrijn ;

Sannerud, Ragna ;

Annaert, Wim ;

May, Patrick C. ;

Karran, Eric ;

De Strooper, Bart .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (10) :8677-8687

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