Senescence-accelerated mouse - Neurochemical studies on aging

被引：49

作者：

Nomura, Y

Yamanaka, Y

Kitamura, Y

Arima, T

Ohnuki, T

Oomura, Y

Sasaki, K

Nagashima, K

Ihara, Y

机构：

[1] TOYAMA MED & PHARMACEUT UNIV, ORIENTAL MED RES INST, DEPT NEUROSCI, TOYAMA 93001, JAPAN

[2] KYOTO PHARMACEUT UNIV, DEPT NEUROBIOL, KYOTO 607, JAPAN

[3] NIPPON ZOKI PHARMACEUT CO LTD, INST BIOACT SCI, YASHIRO, HYOGO 67314, JAPAN

[4] TOYAMA UNIV, FAC ENGN, DEPT ELECT ENGN, TOYAMA 930, JAPAN

[5] HOKKAIDO UNIV, SCH MED, DEPT PATHOL 2, SAPPORO, HOKKAIDO 060, JAPAN

[6] UNIV TOKYO, FAC MED, BRAIN RES INST, DEPT NEUROPATHOL, TOKYO 113, JAPAN

来源：

PHARMACOLOGICAL INTERVENTION IN AGING AND AGE-ASSOCIATED DISORDERS: PROCEEDINGS OF THE SIXTH CONGRESS OF THE INTERNATIONAL ASSOCIATION OF BIOMEDICAL GERONTOLOGY | 1996年 / 786卷

关键词：

D O I：

10.1111/j.1749-6632.1996.tb39080.x

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Senescence-accelerated mouse (SAMPS) is known as a murine model of accelerated aging and memory dysfunction. The binding activity of [ 3H]1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3- isoquinolinecarboxamide (PK-11195) as a neurochemical marker of gliosis markedly increased with aging in the cerebral cortex and hippocampus of SAMPS. Immunoreactivity for glial fibrillary acidic protein (GFAP) was also enhanced. Aβ-amyloid precursor protein (APP)-like immunoreactivity and 27-kDa-carboxyl terminal fragments of APP increased in SAMPS brain. In addition, anti-APP antibody stained reactive astrocytes surrounding spongy degeneration in brain stem of SAMPS. These results suggest that astrocytosis and production of APP-derived fragments occur markedly in SAMPS brains.

引用

页码：410 / 418

页数：9

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