Activated T lymphocytes disappear from circulation during endotoxemia in humans

被引：24

作者：

Krabbe, KS ^{[1
]}

Bruunsgaard, H ^{[1
]}

Qvist, J ^{[1
]}

Fonsmark, L ^{[1
]}

Moller, K ^{[1
]}

Hansen, CM ^{[1
]}

Skinhoj, P ^{[1
]}

Pedersen, BK ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Infect Dis M7641, Rigshosp, DK-2100 Copenhagen, Denmark

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2002年 / 9卷 / 03期

关键词：

D O I：

10.1128/CDLI.9.3.731-735.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA(+) CD45RO(-)) that were less likely to undergo apoptosis (CD28(+)), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.

引用

页码：731 / 735

页数：5

共 16 条

[1]

Aggarwal S, 1998, J IMMUNOL, V160, P1627

[2]

Bruunsgaard H, 1999, CLIN EXP IMMUNOL, V118, P235

[3] DECLINE IN CD28(+) T-CELLS IN CENTENARIANS AND IN LONG-TERM T-CELL CULTURES - A POSSIBLE CAUSE FOR BOTH IN-VIVO AND IN-VITRO IMMUNOSENESCENCE [J].

EFFROS, RB ;

BOUCHER, N ;

PORTER, V ;

ZHU, XM ;

SPAULDING, C ;

WALFORD, RL ;

KRONENBERG, M ;

COHEN, D ;

SCHACHTER, F .

EXPERIMENTAL GERONTOLOGY, 1994, 29 (06) :601-609

[4] Expansion of cytotoxic CD8(+) CD28(-) T cells in healthy ageing people, including centenarians [J].

Fagnoni, FF ;

Vescovini, R ;

Mazzola, M ;

Bologna, G ;

Nigro, E ;

Lavagetto, G ;

Franceschi, C ;

Passeri, M ;

Sansoni, P .

IMMUNOLOGY, 1996, 88 (04) :501-507

[5] Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging [J].

Fagnoni, FF ;

Vescovini, R ;

Passeri, G ;

Bologna, G ;

Pedrazzoni, M ;

Lavagetto, G ;

Casti, A ;

Franceschi, C ;

Passeri, M ;

Sansoni, P .

BLOOD, 2000, 95 (09) :2860-2868

[6] CD28-MEDIATED SIGNALING CO-STIMULATES MURINE T-CELLS AND PREVENTS INDUCTION OF ANERGY IN T-CELL CLONES [J].

HARDING, FA ;

MCARTHUR, JG ;

GROSS, JA ;

RAULET, DH ;

ALLISON, JP .

NATURE, 1992, 356 (6370) :607-609

[7] THE POLYPEPTIDE ENCODED BY THE CDNA FOR HUMAN CELL-SURFACE ANTIGEN FAS CAN MEDIATE APOPTOSIS [J].

ITOH, N ;

YONEHARA, S ;

ISHII, A ;

YONEHARA, M ;

MIZUSHIMA, S ;

SAMESHIMA, M ;

HASE, A ;

SETO, Y ;

NAGATA, S .

CELL, 1991, 66 (02) :233-243

[8] FAS(CD95) FASL INTERACTIONS REQUIRED FOR PROGRAMMED CELL-DEATH AFTER T-CELL ACTIVATION [J].

JU, ST ;

PANKA, DJ ;

CUI, HL ;

ETTINGER, R ;

ELKHATIB, M ;

SHERR, DH ;

STANGER, BZ ;

MARSHAKROTHSTEIN, A .

NATURE, 1995, 373 (6513) :444-448

[9] Ageing is associated with a prolonged fever response in human endotoxemia [J].

Krabbe, KS ;

Bruunsgaard, H ;

Hansen, CM ;

Moller, K ;

Fonsmark, L ;

Qvist, J ;

Madsen, PL ;

Kronborg, G ;

Andersen, HO ;

Skinhoj, P ;

Pedersen, BK .

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2001, 8 (02) :333-338

[10]

LIN E, 1998, ARCH SURG-CHICAGO, V33, P1322

← 1 2 →