The pathobiology of pulmonary hypertension - Smooth muscle cells and ion channels

被引：30

作者：

Michelakis, ED

Weir, EK

机构：

[1] Univ Alberta, Dept Med, Div Cardiol, Vasc Biol Grp, Edmonton, AB T6G 2G7, Canada

[2] Vet Adm Med Ctr, Dept Med, Div Cardiol, Minneapolis, MN 55417 USA

来源：

CLINICS IN CHEST MEDICINE | 2001年 / 22卷 / 03期

基金：

加拿大创新基金会;

关键词：

D O I：

10.1016/S0272-5231(05)70281-1

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Potassium channels regulate both vascular tone and the proliferation status of vascular smooth muscle cells. In this paper we review the role of vascular potassium channels in the pulmonary circulation; we provide evidence from several animal and human models of pulmonary hypertension, supporting the hypothesis that pulmonary arterial smooth muscle potassium channel abnormalities are etiologically related to the pathogenesis of pulmonary hypertension.

引用

页码：419 / +

页数：15

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