Testicular tissue extraction in a young male with 47,XXY Klinefelter's syndrome: Potential strategy for preservation of fertility

被引:53
作者
Damani, MN [1 ]
Mittal, R [1 ]
Oates, RD [1 ]
机构
[1] Boston Univ, Sch Med, Div Urol, Boston, MA 02118 USA
关键词
Klinefelter's syndrome; azoospermia; TESE;
D O I
10.1016/S0015-0282(01)02837-0
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To describe a case involving the cryopreservation of testis tissue retrieved from a 15-year-old male teenager with Klinefelter's syndrome. Design: Case report. Setting: An academic medical center. Patient(s): A 15-year-old boy with Klinefelter's syndrome. Intervention(s): Microsurgical testis sperm extraction with cryopreservation of harvested tissue. Main Outcome Measure(s): Spermatozoa within testis tissue. Result(s): Successful extraction and cryopreservation of three vials of sperm-containing testis tissue. No effect on subsequent testosterone levels. Conclusion(s): Testis tissue extraction in the adequately virilized but azoospermic young male with 47, XXY Klinefelter's syndrome may be a strategy to preserve future biological paternity. (C) 2001 by American Society for Reproductive Medicine.
引用
收藏
页码:1054 / 1056
页数:3
相关论文
共 6 条
[1]   Fertility preservation of boys undergoing anti-cancer therapy: a review of the existing situation and prospects for the future [J].
Aslam, I ;
Fishel, S ;
Moore, H ;
Dowell, K ;
Thornton, S .
HUMAN REPRODUCTION, 2000, 15 (10) :2154-2159
[2]  
FERGUSONSMITH MA, 1959, LANCET, V1, P219
[3]   Analysis of meiosis in intratesticular germ. cells from subjects affected by classic Klinefelter's syndrome [J].
Foresta, C ;
Galeazzi, C ;
Bettella, A ;
Marin, P ;
Rossato, M ;
Garolla, A ;
Ferlin, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (10) :3807-3810
[4]  
MIKAMO K, 1968, FERTIL STERIL, V19, P731
[5]   Testicular sperm extraction: microdissection improves sperm yield with minimal tissue excision [J].
Schlegel, PN .
HUMAN REPRODUCTION, 1999, 14 (01) :131-135
[6]  
TERZOLI G, 1992, FERTIL STERIL, V58, P821